NDLI: Differential scanning calorimetric examination of the degenerated human palmar aponeurosis in dupuytren disease

Content Provider	Springer Nature Link
Author	Wiegand, N. Vámhidy, L. Patczai, B. Dömse, E. Than, P. Kereskai, L. Lőrinczy, D.
Copyright Year	2009
Abstract	The Dupuytren contracture - degenerative shortening of the palmar aponeurosis - is a common disease of the hand in Europe. The aetiology of the degenerative changes in the collagen structures is still not clear. To describe the clinical manifestation of the disease we use an international classification according to Iselin. Our hypothesis was that in Dupuytren disease there is a clear pathological abnormality in the tissue elements building up the palmar aponeurosis, which is responsible for the disease, and could be monitored besides the classical histological methods by differential scanning calorimetry.The thermal denaturation of different parts of human samples was monitored by a SETARAM Micro DSC-II calorimeter. All the experiments were performed between 0 and 100°C. The heating rate was 0.3 K min$^{−1}$. DSC scans clearly demonstrated significant differences between the different types and conditions of samples (control: T $_{m}$=63°C and ΔH $_{cal}$=4.1 J g$^{−1}$, stage I.: T $_{m}$= 63°C and ΔH $_{cal}$=5.1 J g$^{−1}$, stage II.: T $_{m}$=64°C and ΔH $_{cal}$=5.2 J g$^{−1}$, stage III.: T $_{m}$=60°C and ΔH $_{cal}$=5.2 J g$^{−1}$, stage IV.: T $_{m}$=60.2°C and ΔH $_{cal}$=5.3 J g$^{−1}$). The heat capacity change between native and denatured states of aponeurosis samples increased with the degree of structural alterations indicating significant water loosing. These observations could be explained with the structural alterations caused by the biochemical processes.With our investigations we could demonstrate that DSC is a useful and well applicable method for the investigation of collagen tissue of the human aponeurosis. Our results may be of clinical relevance in the future i.e. in the choice of the optimal time of surgical therapy of different clinical level Dupuytren contractures.
Starting Page	797
Ending Page	800
Page Count	4
File Format	PDF
ISSN	13886150
Journal	Journal of thermal analysis
Volume Number	95
Issue Number	3
e-ISSN	15728943
Language	English
Publisher	Springer Netherlands
Publisher Date	2009-03-19
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	DSC Dupuytren contractures Measurement Science, Instrumentation Inorganic Chemistry Polymer Sciences Analytical Chemistry Physical Chemistry
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Condensed Matter Physics

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