NDLI: Incorporation of lipid domains in Cerasome, a morphologically-stable organic-inorganic vesicular nanohybrid

Content Provider	Springer Nature Link
Author	Hashizume, Mineo Saeki, Isamu Otsuki, Masashi Kikuchi, Jun Ichi
Copyright Year	2006
Abstract	To extend the concept of the Cerasome, an organic-inorganic vesicular nanohybrid, this paper investigates the preparation and characterization of a “mixed” Cerasome. The system consists of a Cerasome-forming lipid 1, a cationic synthetic lipid 2, and a zwitterionic phospholipid 3. Lipid mixtures of 1 and 2 or 1 and 3 were used to prepare the mixed Cerasomes. Their lipid distributions were examined using differential scanning calorimetry (DSC), which showed that 1 and 2 (or 1 and 3) were phase-separated in the mixed Cerasomes. These results seem to be mainly attributable to the polymerizable nature of 1. Results of scanning electron microscopy (SEM) and energy-dispersive X-ray analysis (EDX) showed that 1 and 3 were both incorporated into a single Cerasome, not macroscopically separated to form separate vesicles from each lipid component. Mixed Cerasomes of 1 and 2 showed high morphological stability against a membrane-solubilizing surfactant, incorporating up to 70% of 2. On the other hand, the mixed Cerasomes from 1 and 3 were less stable than the mixed Cerasomes from 1 and 2. This relative instability might be attributable to differences between the mixed Cerasomes from 1 and 2 and 1 and 3 in terms of their vesicular sizes, lipid domain sizes, and their relative effectiveness for siloxane network formation. These results strongly support the formation of mixed Cerasomes that have lipid domains in-plane. Systems described in this study are useful to prepare variously mixed Cerasomes that have different surface functionalities and in-plane lipid distribution, but which have high morphological stability.
Starting Page	227
Ending Page	232
Page Count	6
File Format	PDF
ISSN	09280707
Journal	Journal of Sol-Gel Science and Technology
Volume Number	40
Issue Number	2-3
e-ISSN	15734846
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2006-06-27
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cerasome Organic-inorganic nanohybrid Self-assembly Phase separation Lipid domain Inorganic Chemistry Optical and Electronic Materials Nanotechnology Ceramics, Glass, Composites, Natural Methods
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Chemistry Materials Chemistry Biomaterials Condensed Matter Physics Electronic, Optical and Magnetic Materials

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