NDLI: Radiolabeling of EGCG with $^{125}$I and its biodistribution in mice

Content Provider	Springer Nature Link
Author	Diao, Yao Zhao, Wenjin Li, Yaming Liao, Lindan Wang, Ouyue Liu, Jie Zhao, Xun Yu, Chengguo Cui, Zeshi
Copyright Year	2014
Abstract	The aim of the present study was to label EGCG with $^{125}$I and to determine its radiopharmaceutical potential in mice. EGCG was labeled with $^{125}$I using the iodogen method. The labeling yield and the radiochemical purity of $^{125}$I–EGCG were determined by radio thin-layer chromatography (RTLC). The Labeling yield was approximately 89.4 %. The radiochemical purity was approximately 96.4 %. The biodistribution studies of the labeled compound (specific activity; 0.47 TBq/μg) were performed in male Kunming mice. The uptakes of $^{125}$I–EGCG in some organs were determined at different time after injection to the mice. The radioactivity in each organ was counted and the percentage of injected activity per gram of tissue weight (%ID/g) for each organ and blood was calculated. Incorporation of radioactivity in the various tissue/organ was confirmed by microautoradiography. $^{125}$I–EGCG uptake in the stomach and salivary gland was higher than other organ/tissue. The black silver grains was concentrated in the nucleus, cytoplasm, intercellular substance and capillaries of that various organs, and its unevenly distributed. Thus, $^{125}$I–EGCG may be radiopharmaceutical for the imaging of the stomach and salivary gland.
Starting Page	167
Ending Page	173
Page Count	7
File Format	PDF
ISSN	02365731
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume Number	301
Issue Number	1
e-ISSN	15882780
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-04-13
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Epigallocatechingallate $^{125}$I Radiolabeling Biodistribution Microautoradiography Nuclear Chemistry Physical Chemistry Nuclear Physics, Heavy Ions, Hadrons Diagnostic Radiology Inorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Pollution Health, Toxicology and Mutagenesis Radiology, Nuclear Medicine and Imaging Analytical Chemistry Public Health, Environmental and Occupational Health Nuclear Energy and Engineering

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