NDLI: Radical decay in irradiated drugs: Flutamide, ifosfamide

Content Provider	Springer Nature Link
Author	Ambroż, H. B. Kornacka, E. M. Marciniec, B. Przybytniak, G.
Copyright Year	2002
Abstract	Pharmaceuticals sterilized by electron beam irradiation, i.e., flutamide (FA), ifosfamide (IA) and aminoglutethimide (AA), applied in anticancer therapy, were studied in order to determine the kinetics of the radical decay and to find out the structure of some intermediates. Two species identified in flutamide were assigned to a more stable tertiary carbon-centred radical and a less stable aryl radical or nitrogen-centred radical cation. Two components were found in ifosfamide, one belongs to the radical formed on the loss of chlorine atom and another reveals a broad anisotropic signal of hyperfine interaction, a(1P) = 5.3 mT, together with a narrow splitting of 0.7 mT due to unassigned protons. Radiation generates in aminoglutethimide two different, highly populated radical pairs that rearrange in time into more stable radicals. Electron-beam radiolysis induced slightly more paramagnetic species in AA than in IA and about 20 times less than in FA. On a long time scale the decay rates of radicals in irradiated samples increase successively as AA
Starting Page	293
Ending Page	298
Page Count	6
File Format	PDF
ISSN	02365731
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume Number	254
Issue Number	2
e-ISSN	15882780
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2002-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Inorganic Chemistry Physical Chemistry Nuclear Chemistry Diagnostic Radiology Nuclear Physics, Heavy Ions, Hadrons
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Pollution Health, Toxicology and Mutagenesis Radiology, Nuclear Medicine and Imaging Analytical Chemistry Public Health, Environmental and Occupational Health Nuclear Energy and Engineering

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