NDLI: Preparation of $^{99m}$Tc-metronidazole as a model for tumor imaging

Content Provider	Springer Nature Link
Author	Ibrahim, Ismail Taha
Copyright Year	2009
Abstract	Metronidazole (MTNZ) is an antiprotozoa drug, could be labeled with the $^{99m}$Tc. MTZL could be used as an ideal vehicle to deliver radioactive decay energy of $^{99m}$Tc to the sites of tumor, thus facilitate tumor imaging. The process of labeling was done using tin chloride as reducing agent. The optimum conditions required to label 25 μg MTZL were 100 μg stannous chloride, 30 min reaction time, room temperature at pH 7–9 using 0.5 M phosphate buffer. The radiochemical purity of the labeled compound, at the above conditions, was determined using paper chromatography. The yield was about 93%. About 2.5 × l0$^{6}$ of Ehrlich Ascites Carcinoma (EAC) was injected intrapritoneally (i.p) to produce ascites and intramuscularly (i.m) in the right thigh to produce solid tumor in female mice. Biodistribution studies were carried out by injecting solution of $^{99m}$Tc-MTZL in normal and tumor bearing mice. The uptake in ascites was over 5% of the injected dose per gram tissue body weight, at 4 h post injection and above 4% in solid tumor. These data revealed localization of the tracer in the tumor tissues with high percentage sufficient to use $^{99}$ $^{m}$Tc MTZL as promising tool for diagnosis of tumor.
Starting Page	669
Ending Page	674
Page Count	6
File Format	PDF
ISSN	02365731
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume Number	281
Issue Number	3
e-ISSN	15882780
Language	English
Publisher	Springer Netherlands
Publisher Date	2009-09-25
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Metronidazole $^{99m}$Tc Labeling Biodistribution EAC Inorganic Chemistry Diagnostic Radiology Nuclear Physics, Heavy Ions, Hadrons Physical Chemistry Nuclear Chemistry
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Pollution Health, Toxicology and Mutagenesis Radiology, Nuclear Medicine and Imaging Analytical Chemistry Public Health, Environmental and Occupational Health Nuclear Energy and Engineering

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