NDLI: $^{99m}$TcN–gatifloxacin dithiocarbamate complex: a novel multi-drug-resistance Streptococcus pneumoniae (MRSP) infection radiotracer

Content Provider	Springer Nature Link
Author	Shah, Syed Qaiser Khan, Mohammad Rafiullah
Copyright Year	2011
Abstract	Gatifloxacin (GTN) was derivatized to its dithiocarbamate derivative and its radiolabeling with technetium-99m ($^{99m}$Tc) using the [$^{99m}$Tc≡N]$^{2+}$ core was investigated. The appropriateness of the $^{99m}$TcN–gatifloxacin dithiocarbamate ($^{99m}$TcN–GTND) complex as a potential multi-drug-resistance Streptococcus pneumoniae (MRSP) infection radiotracer was evaluated in terms of stability in saline, serum, in vitro binding with MRSP and biodistribution in artificially MRSP infected Male Wistar Rats (MWR). In saline the $^{99m}$TcN–GTND complex showed more than 90% labeling yield up to 4 h with a maximum yield of 98.25 ± 0.20%, after reconstitution. In serum the $^{99m}$TcN–GTND complex showed stability up to 16 h of incubation with the appearance of insignificant 15.95% undesirable side products. The $^{99m}$TcN–GTND complex demonstrated saturated in vitro binding with MRSP with a maximum value of 75.50 ± 1.00% (at 90 min). In MWR model of group A, almost six times higher uptake of the labeled GTND was monitored in the muscle of MWR infected with live MRSP as compared to the inflamed and normal muscles. Based on the higher labeling yield in saline, in vitro stability in serum, saturated in vitro binding with live MRSP and promising biodistribution in MWR model we recommend $^{99m}$TcN–gatifloxacin dithiocarbamate complex as a potential MRSP infection radiotracer.
Starting Page	903
Ending Page	908
Page Count	6
File Format	PDF
ISSN	02365731
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume Number	289
Issue Number	3
e-ISSN	15882780
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-05-28
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	$^{99m}$TcN–GTND complex Multi-drug-resistance Streptococcus pneumoniae (MRSP) Infection Nuclear Physics, Heavy Ions, Hadrons Diagnostic Radiology Nuclear Chemistry Inorganic Chemistry Physical Chemistry
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Pollution Health, Toxicology and Mutagenesis Radiology, Nuclear Medicine and Imaging Analytical Chemistry Public Health, Environmental and Occupational Health Nuclear Energy and Engineering

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