NDLI: Automated synthesis of [$^{18}$F]FMISO on IBA Synthera$^{®}$

Content Provider	Springer Nature Link
Author	Blom, Elisabeth Koziorowski, Jacek
Copyright Year	2013
Abstract	In cancer cells hypoxia can cause resistance to both radio- and chemo-therapy. Being able to quantify, the degree of hypoxia in the cells is a useful tool in therapy planning. The positron emitting 1-[$^{18}$F]fluoro-3-(2-nitro-1H-imidazol-1-yl)propan-2-ol ([$^{18}$F]FMISO) is the most extensively used tracer for imaging hypoxia. Automated synthesis of [$^{18}$F]FMISO was set up on IBA Synthera$^{®}$. The precursor 1-(2′-nitro-1′-imidazolyl)-2-O-tetrahydropyranyl-3-O-p-toluenesulfonyl propanediol (NITTP) was heated at 100 °C for 10 min with [K/K 2.2.2.]$^{+}$[$^{18}$F]$^{−}$ and thereafter hydrolyzed with 0.1 M hydrochloric acid at 90 °C for 2 min. Purification was performed on solid-phase extraction (SPE) cartridges. [$^{18}$F]FMISO was obtained in 50 ± 3 % (n = 6) radiochemical yield (decay-corrected) in 35 min synthesis time with radiochemical purity of ≥98 %. The use of disposable Integrated Fluid Processors (IFP™:s) and cartridge purification simplifies the handling and shortens the synthesis time. This is a no frills setup based on all commercially available materials and the synthesis is performed with minor changes from the FDG time-list.
Starting Page	265
Ending Page	270
Page Count	6
File Format	PDF
ISSN	02365731
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume Number	299
Issue Number	1
e-ISSN	15882780
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-09-14
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	PET FMISO Fluorine-18 Automation Nuclear Chemistry Physical Chemistry Nuclear Physics, Heavy Ions, Hadrons Diagnostic Radiology Inorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Pollution Health, Toxicology and Mutagenesis Radiology, Nuclear Medicine and Imaging Analytical Chemistry Public Health, Environmental and Occupational Health Nuclear Energy and Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Automated production and quality testing of [$^{18}$F]labeled radiotracers using the BG75 system

GMP production of $^{68}$Ga-labelled DOTA-NOC on IBA Synthera

Automated synthesis of hypoxia imaging agent [$^{18}$F]FMISO based upon a modified Explora FDG$_{4}$ module

Simple column purification technique for the fully automated radiosynthesis of 2-[$^{18}$F] fluorine-N-(3-bromophenyl)-6,7-dimethoxyquinazoline-4-amine [2-$^{18}$F-PD153035]

A one-step fully automated radio-synthesis of a dopamine transporter PET imaging agent $^{18}$F-FECNT and its in vivo evaluations

A facile direct nucleophilic synthesis of O-(2-[$^{18}$F]fluoroethyl)-l-tyrosine ([$^{18}$F]FET) without HPLC purification

Fully automated radiosynthesis of [$^{18}$F]Fluoromisonidazole with single neutral alumina column purification: optimization of reaction parameters

PET imaging of prostate cancer with $^{18}$F-Al-NODA-MATBBN

Fully automated synthesis of O-(2′-[$^{18}$F]fluoroethyl)-l-tyrosine ([$^{18}$F]FET) using solid phase extraction (SPE) purification with neutral alumina

Automated synthesis of [$^{18}$F]FMISO on IBA Synthera$^{®}$

Similar Documents

Automated production and quality testing of [$^{18}$F]labeled radiotracers using the BG75 system

GMP production of $^{68}$Ga-labelled DOTA-NOC on IBA Synthera

Automated synthesis of hypoxia imaging agent [$^{18}$F]FMISO based upon a modified Explora FDG$_{4}$ module

Simple column purification technique for the fully automated radiosynthesis of 2-[$^{18}$F] fluorine-N-(3-bromophenyl)-6,7-dimethoxyquinazoline-4-amine [2-$^{18}$F-PD153035]

A one-step fully automated radio-synthesis of a dopamine transporter PET imaging agent $^{18}$F-FECNT and its in vivo evaluations

A facile direct nucleophilic synthesis of O-(2-[$^{18}$F]fluoroethyl)-l-tyrosine ([$^{18}$F]FET) without HPLC purification

Fully automated radiosynthesis of [$^{18}$F]Fluoromisonidazole with single neutral alumina column purification: optimization of reaction parameters

PET imaging of prostate cancer with $^{18}$F-Al-NODA-MATBBN

Fully automated synthesis of O-(2′-[$^{18}$F]fluoroethyl)-l-tyrosine ([$^{18}$F]FET) using solid phase extraction (SPE) purification with neutral alumina

Automated synthesis of [$^{18}$F]FMISO on IBA Synthera$^{®}$