NDLI: Facile radiosynthesis of $^{18}$F-labeled β-glutamic acid as a new PET tracer for imaging lung cancer

Content Provider	Springer Nature Link
Author	Liu, Shaoyu Sun, Aixia Zhang, Zhanwen Nie, Dahong Tang, Xiaolan Ma, Hui Jiang, Shende Tang, Ganghua
Copyright Year	2017
Abstract	In this paper, N-(2-[$^{18}$F]fluoropropionyl)-β-glutamic acid 8 ([$^{18}$F]FP-β-Glu), a new N-substituted $^{18}$F-labeled amino acid tracer, was synthesized from the precursor 4 (diethyl 3-(2-bromopropanamido)pentanedioate) via a two-step reaction on the modified FDG synthesizer. The radiochemical yield was 20 ± 5% (n = 10, decay-corrected) from [$^{18}$F]fluoride within 40 min, the radiochemical purity was 98%. Moreover, microPET studies showed that [$^{18}$F]FP-β-Glu 8 exhibited rapid tumor uptake and good tumor-to-lung ratio in SPC-A-1 tumor-bearing mice. A high accumulation of radioactivity was found in the kidneys and bladder, which suggested that the tracer was mainly eliminated through the urinary system.
Starting Page	233
Ending Page	239
Page Count	7
File Format	PDF
ISSN	02365731
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume Number	312
Issue Number	2
e-ISSN	15882780
Language	English
Publisher	Springer Netherlands
Publisher Date	2017-03-21
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	[$^{18}$F]FP-β-Glu PET imaging Automated radiosynthesis β-Glutamic acid Nuclear Chemistry Physical Chemistry Nuclear Physics, Heavy Ions, Hadrons Diagnostic Radiology Inorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Spectroscopy Pollution Health, Toxicology and Mutagenesis Radiology, Nuclear Medicine and Imaging Analytical Chemistry Public Health, Environmental and Occupational Health Nuclear Energy and Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Semi-automated radiosynthesis of $^{18}$F-labeled l-arginine derivative as a potential PET tracer for lung cancer imaging

Automated synthesis of symmetric integrin α$_{v}$β$_{3}$-targeted radiotracer [$^{18}$F]FP-PEG$_{3}$-β-Glu-RGD$_{2}$

In vivo biodistribution of pancreatic-derived factor using $^{18}$F-labeled PANDER PET imaging

Simple column purification technique for the fully automated radiosynthesis of 2-[$^{18}$F] fluorine-N-(3-bromophenyl)-6,7-dimethoxyquinazoline-4-amine [2-$^{18}$F-PD153035]

(S)-2-((S)-2-(4-(3-[$^{18}$F]fluoropropyl)benzamido)-3-phenylpropanamido)pentanedioic acid labeled with $^{18}$F

Radiosynthesis of 10-(2-[$^{18}$F]fluoroethoxy)-20(S)-camptothecin as a potential positron emission tomography tracer for the imaging of topoisomerase I in cancers

Radiosynthesis of [$^{18}$F]FEt-Tyr-urea-Glu ([$^{18}$F]FEtTUG) as a new PSMA ligand

Automated production and quality testing of [$^{18}$F]labeled radiotracers using the BG75 system

$^{18}$FDG-labeled LIKKPF: a PET tracer for apoptosis imaging

Facile radiosynthesis of $^{18}$F-labeled β-glutamic acid as a new PET tracer for imaging lung cancer

Similar Documents

Semi-automated radiosynthesis of $^{18}$F-labeled l-arginine derivative as a potential PET tracer for lung cancer imaging

Automated synthesis of symmetric integrin α$_{v}$β$_{3}$-targeted radiotracer [$^{18}$F]FP-PEG$_{3}$-β-Glu-RGD$_{2}$

In vivo biodistribution of pancreatic-derived factor using $^{18}$F-labeled PANDER PET imaging

Simple column purification technique for the fully automated radiosynthesis of 2-[$^{18}$F] fluorine-N-(3-bromophenyl)-6,7-dimethoxyquinazoline-4-amine [2-$^{18}$F-PD153035]

(S)-2-((S)-2-(4-(3-[$^{18}$F]fluoropropyl)benzamido)-3-phenylpropanamido)pentanedioic acid labeled with $^{18}$F

Radiosynthesis of 10-(2-[$^{18}$F]fluoroethoxy)-20(S)-camptothecin as a potential positron emission tomography tracer for the imaging of topoisomerase I in cancers

Radiosynthesis of [$^{18}$F]FEt-Tyr-urea-Glu ([$^{18}$F]FEtTUG) as a new PSMA ligand

Automated production and quality testing of [$^{18}$F]labeled radiotracers using the BG75 system

$^{18}$FDG-labeled LIKKPF: a PET tracer for apoptosis imaging

Facile radiosynthesis of $^{18}$F-labeled β-glutamic acid as a new PET tracer for imaging lung cancer