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| Content Provider | Springer Nature Link |
|---|---|
| Author | Bagheri, Massoumeh Bigdeli, Elham |
| Copyright Year | 2013 |
| Abstract | Novel amphiphilic brush copolymers, P(CPLAMA)-co-P(PEGMA), of cholesteryl poly(l-lactic acid) (CPLA) and poly(ethylene glycol) monomethyl ether (PEG) with determined hydrophobic/hydrophilic ratios were synthesized by the methacrylate (MA) macromonomer copolymerization method. Brush copolymers were prepared via both free radical polymerization (FRP) and atom transfer radical polymerization (ATRP). The copolymer compositions were determined by $^{1}$H NMR spectroscopy. The synthesized copolymers were used to prepare the micellar nanoparticles with hydrophobic CPLA and hydrophilic PEG forming the core and shell, respectively. The critical micelle concentration (CMC) values of the samples produced by FRP (brush copolymer 1) and ATRP (brush copolymer 2) were estimated to be approximately 0.9 and 0.7 mg/L in aqueous solution by a fluorescence probe technique, respectively. The transmission electron microscopy (TEM) images of micelles of the brush copolymers 1 and 2 showed that micelles were spherical in shape with a mean diameter of 111 and 32 nm, respectively. The results showed that the size of micelles became larger with the increase of the molecular weight of polymer and the relative content of the hydrophilic PEG as well. The drug loading efficiency and drug-releasing properties of the micelles were investigated by using naproxen as a hydrophobic model drug. The in vitro release of naproxen-loaded micelles with about 85–89 % loading efficiency and 17–18 % loading capacity was studied by a using dialysis method in phosphate-buffered solution at 37 °C. The drug-releasing characteristics exhibited a phase of slow release. On the basis of the results obtained, the proposed brush copolymers may be useful in various targeted drug delivery applications, especially those involving hydrophobic drugs. |
| Starting Page | 1 |
| Ending Page | 11 |
| Page Count | 11 |
| File Format | |
| ISSN | 10229760 |
| Journal | Journal of Polymer Research |
| Volume Number | 20 |
| Issue Number | 3 |
| e-ISSN | 15728935 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2013-02-03 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | l-Lactide Cholesterol Poly(ethylene glycol) Brush copolymer Macromonomer Stealth micelles Polymer Sciences Industrial Chemistry/Chemical Engineering Characterization and Evaluation of Materials |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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