NDLI: Solubilization of Clonazepam, Diazepam and Lamotrigine Using Ethanol and Sodium Dodecyl Sulfate

Content Provider	Springer Nature Link
Author	Jouyban, Abolghasem Panahi Azar, Vahid Fakhree, Mohammad A. A. Ahmadian, Somaieh
Copyright Year	2014
Abstract	The apparent solubilities of clonazepam, diazepam and lamotrigine in binary mixtures of ethanol + water at 298.2 K in the presence of three different concentrations of sodium dodecyl sulfate (SDS) are reported. Using this approach, 2250, 7733, and 153 times enhancement in the aqueous solubility of clonazepam, diazepam, and lamotrigine were achieved, respectively. Melting point and polar surface area were determined as indicators of solubility enhancement by SDS and ethanol, respectively. The Jouyban–Acree model was used for correlating the reported data and the obtained mean relative deviations are 7.2, 10.0 and 7.9 %, respectively. When all data points of clonazepam, diazepam and lamotrigine in binary solvents at various SDS concentrations were fitted to the model, the mean relative deviations are 10.0, 17.3, and 11.8 %, respectively. The results reveal that the model could be used for mathematical representation of cosolvent and surfactant concentrations on the solubility of these pharmaceuticals. This study shows that for aqueous solutions SDS is a solubility enhancer in the presence of organic solvents and this could be helpful in reducing the need for organic solvents in pharmaceutical dosage forms where avoidance of higher concentrations of organic solvents is desirable.
Starting Page	1997
Ending Page	2009
Page Count	13
File Format	PDF
ISSN	00959782
Journal	Journal of Solution Chemistry
Volume Number	43
Issue Number	11
e-ISSN	15728927
Language	English
Publisher	Springer US
Publisher Date	2014-11-05
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Solubility Diazepam Clonazepam Lamotrigine Ethanol Solvent mixture Sodium dodecyl sulfate Jouyban–Acree model Physical Chemistry Industrial Chemistry/Chemical Engineering Geochemistry Oceanography Inorganic Chemistry Condensed Matter Physics
Content Type	Text
Resource Type	Article
Subject	Biochemistry Molecular Biology Biophysics Physical and Theoretical Chemistry

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