NDLI: Protonation Constants of Some Alanyl Dipeptides in Mixed Aqueous Organic Solvents

Content Provider	Springer Nature Link
Author	Aslan, Nazife Erden, Pınar Esra Doğan, Alev Canel, Esin Kılıç, Esma
Copyright Year	2016
Abstract	The stochiometric protonation constants of (log$_{10}$ K $_{1}$ and log$_{10}$ K $_{2}$) some alanyl dipeptides (Ala–Tyr, Ala–Phe, Ala–Val, Ala–Leu, Ala–Ala and Ala–Met) were determined in binary mixtures of water with 1,4-dioxane and dimethylsulfoxide containing 20, 40 and 60 % (v/v), using a potentiometric titration method at 25 ± 0.1 °C and constant ionic strength of 0.10 mol·L$^{−1}$ sodium chloride. The autoprotolysis constant values (K $_{ap}$) of the media were also determined for each solvent mixture. The protonation constants of the dipeptides were calculated with the computer program BEST and selection of the best fit chemical models was based on the statistical parameters. The effects of the different amino acids bound to the alanine on the acidity of the alanyl dipeptides have been investigated. Finally, the results are discussed in terms of the effect of the solvent composition on the protonation constants.
Starting Page	299
Ending Page	312
Page Count	14
File Format	PDF
ISSN	00959782
Journal	Journal of Solution Chemistry
Volume Number	45
Issue Number	2
e-ISSN	15728927
Language	English
Publisher	Springer US
Publisher Date	2016-02-05
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Dimethyl sulfoxide 1,4-Dioxane Protonation constants BEST Alanyl dipeptides Physical Chemistry Industrial Chemistry/Chemical Engineering Geochemistry Oceanography Inorganic Chemistry Condensed Matter Physics
Content Type	Text
Resource Type	Article
Subject	Biochemistry Molecular Biology Biophysics Physical and Theoretical Chemistry

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