NDLI: Effects of the nature of counterions in solution on interactions of phenoxazones, xanthones, and carbazoles containing benzo-crown groups with DNA

Content Provider	Springer Nature Link
Author	Moroshkina, E. B. Bogdav, A. A. Kolonistova, M. O. Sedova, O. B. Urusova, T. A.
Copyright Year	2009
Abstract	The interactions of DNA with phenoxazones, xanthones, and carbazoles containing the (benzo-18-crown-6)-4′-yl and (benzo-15-crown-5)-4′-yl radicals bonded to the chromophore via spacers of different lengths in the presence of Na$^{+}$ and K$^{+}$ ions were studied by spectrophotometry, circular dichroism, and dynamic birefringence. The thermodynamic parameters of the binding of the compounds with DNA and changes in the macromolecular parameters of the DNA molecule during complexation were determined. Based on the results of these studies, we suggested the models of bonding of these compounds to the double helix of DNA. It is shown that the mode of DNA binding with a phenoxazone derivative containing two (benzo-15-crown-5)-4′-yl radicals bonded via a fragment of glycine to chromophore depends on the type of the counterion in solution. In the presence of Na$^{+}$, the chromophore is intercalated into the double helix of DNA; in the presence of K$^{+}$, it is bound to DNA in the form of a dimer outside the double helix. The type of the counterion does not affect the mode of binding of other crown-containing compounds of actinocin with DNA. For compounds containing the (benzo-18-crown-6)-4′-yl radical, the mode of binding to DNA adepends only on the spacer length.
Starting Page	989
Ending Page	995
Page Count	7
File Format	PDF
ISSN	00224766
Journal	Journal of Structural Chemistry
Volume Number	50
Issue Number	5
e-ISSN	15738779
Language	English
Publisher	Springer US
Publisher Date	2010-01-28
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	DNA benzo-crown-containing phenoxazones xanthones and carbazoles spectrophotometry circular dichroism viscosimetry optical anisotropy interaction intercalation Solid State Physics Atomic/Molecular Structure and Spectra Atomic, Molecular, Optical and Plasma Physics Physical Chemistry Inorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Materials Chemistry Physical and Theoretical Chemistry Inorganic Chemistry

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