NDLI: Modification of inorganic porous materials as gene vectors: an overview

Content Provider	Springer Nature Link
Author	Liu, Feng Guo Zhao, Li Zhi An, Ning Tong, Dong Shen Yu, Wei Hua Zhou, Chun Hui
Copyright Year	2015
Abstract	The use of porous materials as gene vectors is becoming more important and striking than their traditional uses in catalysis and separation. This article highlights recent advances in the modification of typical inorganic porous materials which are specifically and necessarily conducted for their uses as gene vectors. Literature survey indicates that carbon nanotubes, layered double hydroxides, mesoporous silica and carbon nanoparticles and the related hierarchical materials have received particular attention in recent years. Though these inorganic porous materials have high surface area and porosity, to choose surface modification judiciously is often required for improving their performances in the loading of genes, targeted delivery and controlled release of genes. Major modification methods are adsorption or grafting of other molecules onto the surface of these inorganic porous materials. In addition, modification by adding magnetic nanoparticles to the porous materials has been investigated. Nevertheless, thus far most studies on the modification have aimed merely at the improvement of the loading, the delivery and the release of gene. Exact biocompatibility and in vivo therapy effectiveness remains elusive and are still in question.
Starting Page	927
Ending Page	937
Page Count	11
File Format	PDF
ISSN	13802224
Journal	Journal of Porous Materials
Volume Number	22
Issue Number	4
e-ISSN	15734854
Language	English
Publisher	Springer US
Publisher Date	2015-05-13
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Gene vector Porous materials Nanotube Layered double hydroxides Mesoporous silica Cancer therapy Catalysis Characterization and Evaluation of Materials Physical Chemistry
Content Type	Text
Resource Type	Article
Subject	Mechanics of Materials Materials Science Mechanical Engineering

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