NDLI: A new approach to the compartmental analysis in pharmacokinetics: fractional time evolution of diclofenac

Content Provider	Springer Nature Link
Author	Popović, Jovan K. Atanacković, Milica T. Pilipović, Ana S. Rapaić, Milan R. Pilipović, Stevan Atanacković, Teodor M.
Copyright Year	2010
Abstract	This study presents a new two compartmental model and its application to the evaluation of diclofenac pharmacokinetics in a small number of healthy adults, during a bioequivalence trial. In the model the integer order derivatives are replaced by derivatives of real order often called fractional order derivatives. Physically that means that a history (memory) of a biological process, realized as a transfer from one compartment to another one with the mass balance conservation, is taken into account. This kind of investigations in pharmacokinetics is founded by Dokoumetzidis and Macheras through the one compartmental models while our contribution is the analysis of multi-dimensional compartmental models with the applications of the two compartmental model in evaluation of diclofenac pharmacokinetics. Two experiments were preformed with 12 healthy volunteers with two slow release 100 mg diclofenac tablet formulations. The agreement of the values predicted by the proposed model with the values obtained through experiments is shown to be good. Thus, pharmacokinetics of slow release diclofenac can be described well by a specific two compartmental model with fractional derivatives of the same order. Parameters in the model are determined by the least-squares method and the Particle Swarm Optimization (PSO) numerical procedure is used. The results show that the fractional order two compartmental model for diclofenac is superior in comparison to the classical two compartmental model. Actually this is true in general case since the classical one is a special case of the fractional one.
Starting Page	119
Ending Page	134
Page Count	16
File Format	PDF
ISSN	1567567X
Journal	Journal of Pharmacokinetics and Pharmacodynamics
Volume Number	37
Issue Number	2
e-ISSN	15738744
Language	English
Publisher	Springer US
Publisher Date	2010-01-14
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Fractional kinetics Multicompartmental model Computer simulation Diclofenac bioequivalence Biochemistry Biomedical Engineering Veterinary Medicine Pharmacy Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Pharmacology

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Erratum to: A new approach to the compartmental analysis in pharmacokinetics: fractional time evolution of diclofenac

Erratum to: A new approach to the compartmental analysis in pharmacokinetics: fractional time evolution of diclofenac

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