NDLI: Characterization and Release Kinetics of Allylthiosufinate and its Transforments from Poly(d,l-Lactide) Microspheres

Content Provider	Springer Nature Link
Author	Ilić, Dušica Ristić, Ivan S. Nikolić, Ljubiša Stanković, Mihajlo Nikolić, Goran Stajević, Ljiljana Nikolić, Vesna
Copyright Year	2011
Abstract	In this work was described poly(d,l-lactide) microwave synthesis using tin(II) 2-ethylhexanoate initiated ring-opening polymerization. Polymerization was performed at 100 °C with monomer to initiator molar ratio ([M]/[I]) of 5,000 in 30 min. The achieved number average molar mass of obtained polymers (determined by gel permeation chromatography) was 102,320 g/mol, with the polydispersion index, Q, 2.80. Structural characterization was performed by FT-IR spectroscopy followed characteristic bands. For applicative purposes the obtained polymer was purified during the procedure of microsphere preparation. Biodegradable microspheres prepared from poly(d,l-lactide) have been widely studied in recent years and have become well established controlled drug delivery systems. In this work microspheres were loaded with allyl thiosulfinate (allicin) and its transforments products (ajoene and vinyldithiine), as pharmacological active substances. The morphology of the microspheres was analyzed using a scanning electron microscope. Allicin was synthesized by acid oxidation of allyl disufide and purification of obtained products by liquid–liquid extraction with diethyl ether. Obtained allicin, purity 73%, was transformed using microwave in acetone solution, at solvent boiling temperature, for 5 min. For the quality and quantity analysis of allicin and its transformation process was used LC/MS chromatography. (E)- and (Z)-ajoene were detected at retention time 3.1 and 3.3 min, respectively, whence 3-vynil-4H-1,2-dithiine and 2-vynil-4H-1,3-dithiine were detected at 4.3 and 4.8 min, respectively. Retention time of allicin was 2.93 min, according to liquid chromatography results. HPLC method was used for assessment of pharmaceutical substances (alicine and alicine transforments) releasing from microspheres at room temperature in solutions with different pH (pH = 3 and pH = 8) for 24 h.
Starting Page	80
Ending Page	87
Page Count	8
File Format	PDF
ISSN	15662543
Journal	Journal of Polymers and the Environment
Volume Number	20
Issue Number	1
e-ISSN	15728900
Language	English
Publisher	Springer US
Publisher Date	2011-08-03
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Poly(d,l-lactide) Microspheres Allicin Ajoene Vinyldithiine Microwave polymerization Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Materials Chemistry Environmental Engineering Polymers and Plastics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The Properties of Poly(l-Lactide) Prepared by Different Synthesis Procedure

Formation of Poly(L-lactide) mesophase and its chain mobility dependent kinetics

Synthesis and characterization of star-shaped poly(d,l-lactide)-block-poly(ethylene glycol) copolymers

Synthesis and characterization of novel maleated poly(d,l-lactide-co-glycolide) by direct melt copolymerization

Design of polylactide-grafted copolymeric stabilizer for dispersion polymerization of D,L-lactide

Synthesis and Properties of Poly(d,l-lactide-co-p-dioxanone) Random and Segmented Copolymers

Poly(l-lactide) initiated by silver N-heterocyclic carbene complexes: synthesis, characterization and properties

Suspension Polymerization of Poly(l-lactide-co-p-dioxanone) in Supercritical Carbon Dioxide

Synthesis and characterization of star-shaped poly(l-lactide)s with an erythritol core and evaluation of their rifampicin-loaded microspheres for controlled drug delivery

Characterization and Release Kinetics of Allylthiosufinate and its Transforments from Poly(d,l-Lactide) Microspheres

Similar Documents

The Properties of Poly(l-Lactide) Prepared by Different Synthesis Procedure

Formation of Poly(L-lactide) mesophase and its chain mobility dependent kinetics

Synthesis and characterization of star-shaped poly(d,l-lactide)-block-poly(ethylene glycol) copolymers

Synthesis and characterization of novel maleated poly(d,l-lactide-co-glycolide) by direct melt copolymerization

Design of polylactide-grafted copolymeric stabilizer for dispersion polymerization of D,L-lactide

Synthesis and Properties of Poly(d,l-lactide-co-p-dioxanone) Random and Segmented Copolymers

Poly(l-lactide) initiated by silver N-heterocyclic carbene complexes: synthesis, characterization and properties

Suspension Polymerization of Poly(l-lactide-co-p-dioxanone) in Supercritical Carbon Dioxide

Synthesis and characterization of star-shaped poly(l-lactide)s with an erythritol core and evaluation of their rifampicin-loaded microspheres for controlled drug delivery

Characterization and Release Kinetics of Allylthiosufinate and its Transforments from Poly(d,l-Lactide) Microspheres