NDLI: Direct Numerical Simulation of Single Leukocyte Deformation in Microchannel Flow for Disease Diagnosis

Content Provider	Springer Nature Link
Author	Luo, Z. Y. Xu, F. Lu, T. J. Bai, B. F.
Copyright Year	2010
Abstract	To better understand the physical mechanism of leukocyte separation via microfluidics, a level set method was employed to analyze the coupled deformation-flow of individual leukocytes in microfluidic parabolic shear blood flow. The results show that: (1) Weber number and viscosity ratio have great effects on the deformation of single leukocyte, (2) difference between the deformation and motion behavior of different subtypes of leukocytes (i.e., granulocytes, lymphocytes, monocytes) was observed, and (3) the existence of a second leukocyte significantly changes the leukocyte deformation and motion. These results shed light on the understanding of the motion and deformation of leukocytes in microchannel flow and provide a theoretical foundation for separating lymphocytes via microfluidics.
Starting Page	869
Ending Page	876
Page Count	8
File Format	PDF
ISSN	01485598
Journal	Journal of Medical Systems
Volume Number	35
Issue Number	5
e-ISSN	1573689X
Language	English
Publisher	Springer US
Publisher Date	2010-05-05
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Single leukocyte Deformation Microfluidics Level set method Statistics for Life Sciences, Medicine, Health Sciences Health Informatics
Content Type	Text
Resource Type	Article
Subject	Health Information Management Information Systems Health Informatics

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Direct Numerical Simulation of Single Leukocyte Deformation in Microchannel Flow for Disease Diagnosis