NDLI: A statistical mechanics description of environmental variability in metabolic networks

Content Provider	Springer Nature Link
Author	Crofts, Jonathan J. Estrada, Ernesto
Copyright Year	2013
Abstract	Many of the chemical reactions that take place within a living cell are irreversible. Due to evolutionary pressures, the number of allowable reactions within these systems are highly constrained and thus the resulting metabolic networks display considerable asymmetry. In this paper, we explore possible evolutionary factors pertaining to the reduced symmetry observed in these networks, and demonstrate the important role environmental variability plays in shaping their structural organization. Interpreting the returnability index as an equilibrium constant for a reaction network in equilibrium with a hypothetical reference system, enables us to quantify the extent to which a metabolic network is in disequilibrium. Further, by introducing a new directed centrality measure via an extension of the subgraph centrality metric to directed networks, we are able to characterise individual metabolites by their participation within metabolic pathways. To demonstrate these ideas, we study 116 metabolic networks of bacteria. In particular, we find that the equilibrium constant for the metabolic networks decreases significantly in-line with variability in bacterial habitats, supporting the view that environmental variability promotes disequilibrium within these biochemical reaction systems.
Starting Page	675
Ending Page	688
Page Count	14
File Format	PDF
ISSN	02599791
Journal	Journal of Mathematical Chemistry
Volume Number	52
Issue Number	2
e-ISSN	15728897
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-11-12
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Complexity Metabolic networks Returnability Centrality Physical Chemistry Theoretical and Computational Chemistry Math. Applications in Chemistry
Content Type	Text
Resource Type	Article
Subject	Applied Mathematics Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Returnability as a criterion of disequilibrium in atmospheric reactions networks

Centrality measure in graphs

Statistical properties of carbon nanostructures

Doppelgänger entropies

Description of the kinetics of a model tribopolymerization process

Torsion in biochemical reaction networks

Information-theoretical complexity for the hydrogenic identity S $_{ N }$2 exchange reaction

Eigenvalues of a statistical mechanics matrix

Erratum to: The complexity of Platonic and Archimedean polyhedral links

A statistical mechanics description of environmental variability in metabolic networks

Similar Documents

Returnability as a criterion of disequilibrium in atmospheric reactions networks

Centrality measure in graphs

Statistical properties of carbon nanostructures

Doppelgänger entropies

Description of the kinetics of a model tribopolymerization process

Torsion in biochemical reaction networks

Information-theoretical complexity for the hydrogenic identity S $_{ N }$2 exchange reaction

Eigenvalues of a statistical mechanics matrix

Erratum to: The complexity of Platonic and Archimedean polyhedral links

A statistical mechanics description of environmental variability in metabolic networks