NDLI: Lung Cancer Detection by Native Fluorescence Spectra of Body Fluids

Content Provider	Springer Nature Link
Author	Al Salhi, Mohammad Masilamani, Vadivel Vijmasi, Trinka Al Nachawati, Hicham VijayaRaghavan, A. P.
Copyright Year	2010
Abstract	Lung cancer takes a heavy toll every year, since the survival rate is not more than 15%. In this paper, we present results of a novel technique based on the autofluorescence of body fluids like blood plasma, acetone extract of cellular components, sputa and urine of lung cancer patients (N = 27). A set of ratio parameters based on the fluorescence peaks of tryptophan and elastin, in plasma and sputum; flavin, NADH (reduced nicotinamide adenine dinucleotide) and porphyrin in urine; porphyrin alone in acetone extract of formed elements, were all evaluated. Similar sets of ratios were obtained for age adjusted normal controls (N = 27) and all these ratios were given as inputs to multivariate (principle component and discriminant) analyses, which showed that the two groups could be classified with an accuracy of about 90%. Since the instrumentation involved was an ordinary steady state Xe lamp based spectrofluorometer, the technique is of significant advantage in screening and early detection of lung cancer in high risk population such as heavy smokers.
Starting Page	637
Ending Page	645
Page Count	9
File Format	PDF
ISSN	10530509
Journal	Journal of Fluorescence
Volume Number	21
Issue Number	2
e-ISSN	15734994
Language	English
Publisher	Springer US
Publisher Date	2010-10-19
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lung cancer detection Biomarkers Native fluorescence Spectroscopy Blood plasma Urine Sputum Biotechnology Biophysics and Biological Physics Biomedicine general Biochemistry Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Sociology and Political Science Spectroscopy Law Biochemistry Clinical Biochemistry Clinical Psychology

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