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| Content Provider | Springer Nature Link |
|---|---|
| Author | Belal, Tarek Saied |
| Copyright Year | 2008 |
| Abstract | A simple, rapid, selective and sensitive spectrofluorimetric method was described for the analysis of three nitrofuran drugs, namely, nifuroxazide (NX), nitrofurantoin (NT) and nitrofurazone (NZ). The method involved the alkaline hydrolysis of the studied drugs by warming with 0.1 M sodium hydroxide solution then dilution with distilled water for NX or 2-propanol for NT and NZ. The formed fluorophores were measured at 465 nm (λ $_{Ex}$ 265 nm), 458 nm (λ $_{Ex}$ 245 nm) and 445 nm (λ $_{Ex}$ 245 nm) for NX, NT and NZ, respectively. The reaction pathway was discussed and the structures of the fluorescent products were proposed. The different experimental parameters were studied and optimized. Regression analysis showed good correlation between fluorescence intensity and concentration over the ranges 0.08–1.00, 0.02–0.24 and 0.004–0.050 μg ml$^{−1}$ for NX, NT and NZ, respectively. The limits of detection of the method were 8.0, 1.9 and 0.3 ng ml$^{−1}$ for NX, NT and NZ, respectively. The proposed method was validated in terms of accuracy, precision and specificity, and it was successfully applied for the assay of the three nitrofurans in their different dosage forms. No interference was observed from common pharmaceutical adjuvants. The results were favorably compared with those obtained by reference spectrophotometric methods. |
| Starting Page | 771 |
| Ending Page | 780 |
| Page Count | 10 |
| File Format | |
| ISSN | 10530509 |
| Journal | Journal of Fluorescence |
| Volume Number | 18 |
| Issue Number | 5 |
| e-ISSN | 15734994 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2008-02-01 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Nitrofuran drugs Nifuroxazide Nitrofurantoin Nitrofurazone Spectrofluorimetric determination Pharmaceutical preparations Analytical Chemistry Biochemistry Biotechnology Biophysics/Biomedical Physics Biomedicine general |
| Content Type | Text |
| Resource Type | Article |
| Subject | Sociology and Political Science Spectroscopy Law Biochemistry Clinical Biochemistry Clinical Psychology |
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