NDLI: Comparative-physiological study of leukocyte participation in initiation of lipid peroxidation during nitrite intoxication in rats and muskrats

Content Provider	Springer Nature Link
Author	Tsoi, E. M. Kovalenko, R. I. Kuz’min, D. A.
Copyright Year	2008
Abstract	The study is carried out on Wistar white rats non-adapted to oxygen deficit and on semiaquatic rodents muskrats adapted to periodic arrest of respiration during diving under conditions of Nembutal narcosis. It has been revealed that 1 h after a subcutaneous injection of sodium nitrite (3 mg/100 g body mass), intensification of lipid peroxidation (LPO) in the muskrat brain is absent, the activity of the antioxidant enzyme catalase increasing 16 times (p < 0.01) as compared with control injected with equivalent saline volume. In heart and liver, there was a statistically significant decrease of the content of LPO products active in the test with 2-thiobarbituric acid; in the femoral muscle tissue, the LPO intensity did not change. In rats, unlike muskrats, after injection of sodium nitrite, an increase of LPO is recorded in brain, while a decrease of the LPO product content in the femoral muscle; in liver the LPO intensity did not change. In muskrats, the sodium nitrite administration led to a decrease of the leukocyte spontaneous mobility, of lymphocyte cytokine-producing activity, and of neutrophil bactericidal activity (by the content of cationic proteins in neutrophilic phagocytes), whereas in rats the leukocyte mobility did not change, only the blood neutrophil bactericidal activity decreased. The ability of neutrophils to produce the superoxide anion during the nitrite intoxication did not change both in rats and in muskrats. The obtained data allow concluding that under conditions of Nembutal narcosis the leukocyte functional activity on the background of nitrite intoxication is suppressed to the greater degree in the muskrats genotypically adapted to oxygen deficit than in immunocompetent cells of the rodents not adapted to hypoxia.
Starting Page	476
Ending Page	483
Page Count	8
File Format	PDF
ISSN	00220930
Journal	Journal of Evolutionary Biochemistry and Physiology
Volume Number	44
Issue Number	4
e-ISSN	16083202
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2008-10-18
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	hypoxia nitrite intoxication lipid peroxidation catalase leukocyte functional activity migration Animal Physiology Biochemistry Evolutionary Biology
Content Type	Text
Resource Type	Article
Subject	Physiology Biochemistry Ecology, Evolution, Behavior and Systematics

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