NDLI: Effect of prenatal hypobaric hypoxia on activity of the rat brain phosphoinositide system

Content Provider	Springer Nature Link
Author	Tyulkova, E. I. Vataeva, L. A. Samoilov, M. O.
Copyright Year	2010
Abstract	Activity of the phosphoinositide system of intracellular signalization was studied in offspring of rats exposed to severe hypobaric hypoxia at the 14–16th (group 1) or the 18–20th day (group 2) of prenatal hypoxia. At the age of 15 days, in animals of both experimental groups the basal level of triphosphoinositides in the brain cortex was shown to be elevated as compared with control. In the group 1, this parameter also remains elevated in adult animals. Application of glutamate produces a more pronounced increase of the inositephosphates in brain slices of the 15-day old rats of the group 1 than in slices of animals of the control group. In the 15-day old rats of the group 2, as compared with control, the phosphoinositide response to glutamate application was reduced. No changes in the inositephosphate levels were revealed after application of glutamate upon slices of adult (the 90-day old) control animals and of adult rats of the group 2. In slices of adult rats of the group 1, on the contrary, the glutamate application produced an increase of the inositephosphate content. The obtained data indicate essential changes of the phosphoinositide metabolism in the brain of rats exposed to action of hypoxia at the period of prenatal development. The character and the severity of these changes depend on the period of development when action of hypoxia occurs.
Starting Page	484
Ending Page	488
Page Count	5
File Format	PDF
ISSN	00220930
Journal	Journal of Evolutionary Biochemistry and Physiology
Volume Number	46
Issue Number	5
e-ISSN	16083202
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2010-12-14
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	prenatal hypoxia polyphosphoinositides brain rat Animal Physiology Biochemistry Evolutionary Biology
Content Type	Text
Resource Type	Article
Subject	Physiology Biochemistry Ecology, Evolution, Behavior and Systematics

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