NDLI: Distribution of the Human Immunodeficiency Virus Coreceptors CXCR4 and CCR5 on Leukocytes of Persons with Human Immunodeficiency Virus Type 1 Infection and Pulmonary Tuberculosis: Implications for Pathogenesis

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Distribution of the Human Immunodeficiency Virus Coreceptors CXCR4 and CCR5 on Leukocytes of Persons with Human Immunodeficiency Virus Type 1 Infection and Pulmonary Tuberculosis: Implications for Pathogenesis

IFN-α Acts on T-Cell Receptor-Triggered Human Peripheral Leukocytes to Up-Regulate CCR5 Expression on CD4+ and CD8+ T Cells

Molecular Determinants of the Human Antibody Response to HIV-1: Implications for Disease Control

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Journal of Clinical Immunology : Volume 21, Issue 5, September 2001

Journal of Clinical Immunology : Volume 21, Issue 4, July 2001

Journal of Clinical Immunology : Volume 21, Issue 3, May 2001

Journal of Clinical Immunology : Volume 21, Issue 2, March 2001

Journal of Clinical Immunology : Volume 21, Issue 1, January 2001

Journal of Clinical Immunology : Volume 20

Journal of Clinical Immunology : Volume 19

Journal of Clinical Immunology : Volume 18

Journal of Clinical Immunology : Volume 17

Distribution of the Human Immunodeficiency Virus Coreceptors CXCR4 and CCR5 on Leukocytes of Persons with Human Immunodeficiency Virus Type 1 Infection and Pulmonary Tuberculosis: Implications for Pathogenesis

Content Provider	Springer Nature Link
Author	Shalekoff, Sharon Pendle, Stella Johnson, Dave Martin, Desmond J. Tiemessen, Caroline T.
Copyright Year	2001
Abstract	Expression of CXCR4 was significantly reduced from normal on all cell subsets of persons with pulmonary tuberculosis (TB group), with HIV-1 infection (HIV group), and those with both infections (HIV/TB group), except for on monocytes in the HIV group. The reductions were most notable in the two TB groups. Interestingly, the duration of antituberculosis treatment was significantly negatively correlated with the expression of CXCR4 on CD4$^{+}$ and CD8$^{+}$CD45RO$^{+}$ cells, monocytes and NK cells, viral load, and proportions of CD38-expressing CD8$^{+}$ lymphocytes, in HIV/TB patients. By contrast, CCR5 expression on most cell subsets analyzed was increased in all the disease groups, except for on monocytes in the two TB groups. There was no change in CCR5 expression on CD4$^{+}$ cells when based on the disease groupings. However, higher proportions of CD4$^{+}$CD45RA$^{+}$ and CD8$^{+}$ lymphocytes as well as B cells expressing CCR5 correlated with advancing HIV-1 disease, as did decreased proportions of CXCR4-expressing CD4$^{+}$CD45RA$^{+}$ cells.
Starting Page	390
Ending Page	401
Page Count	12
File Format	PDF
ISSN	02719142
Journal	Journal of Clinical Immunology
Volume Number	21
Issue Number	6
e-ISSN	15732592
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2001-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Immunology Medical Microbiology Internal Medicine Infectious Diseases
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Distribution of the Human Immunodeficiency Virus Coreceptors CXCR4 and CCR5 on Leukocytes of Persons with Human Immunodeficiency Virus Type 1 Infection and Pulmonary Tuberculosis: Implications for Pathogenesis

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