NDLI: Phellinus tropicalis Abscesses in a Patient with Chronic Granulomatous Disease

Content Provider	Springer Nature Link
Author	Ramesh, Manish Resnick, Elena Hui, Yiqun Maglione, Paul J. Mehta, Harshna Kattan, Jacob Bouvier, Nicole M. LaBombardi, Vincent Victor, Tanya R. Chaturvedi, Sudha Cunningham Rundles, Charlotte
Copyright Year	2013
Abstract	Chronic Granulomatous Disease (CGD), caused by genetic defects in components of the phagocyte NADPH oxidase pathway, leads to recurrent life-threatening bacterial and invasive fungal infections. While a number of unique pathogens have been associated with this disease, the causative organisms may be difficult to identify. Here, we present a 24 year old male with known X-linked CGD who concurrently developed a cervical abscess and an abscess in the subcutaneous tissues of the right hip, both of which were surgically drained. Cultures failed to identify any organisms. He was treated empirically with ertapenem but the hip abscess recurred at the original site and in contiguous dependent areas in the posterior thigh and knee. A filamentous organism was observed microscopically, initially considered a contaminant, but on culture yielded a mold growth, identified as Phellinus tropicalis (synonym: Inonotus tropicalis) based on phenotypic and molecular methods. This is the third case report of human infection with P. tropicalis, all in subjects with CGD. The patient was treated with voriconazole with resolution of his symptoms.
Starting Page	130
Ending Page	133
Page Count	4
File Format	PDF
ISSN	02719142
Journal	Journal of Clinical Immunology
Volume Number	34
Issue Number	2
e-ISSN	15732592
Language	English
Publisher	Springer US
Publisher Date	2013-12-06
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Chronic granulomatous disease Phellinus tropicalis abscess voriconazole Immunology Infectious Diseases Internal Medicine Medical Microbiology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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