NDLI: Rapid Disease Progression in HIV-1-Infected Men Who Have Sex with Men Is Negatively Correlated with Peripheral Plasmacytoid Dendritic Cell Counts at the Early Stage of Primary Infection

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Rapid Disease Progression in HIV-1-Infected Men Who Have Sex with Men Is Negatively Correlated with Peripheral Plasmacytoid Dendritic Cell Counts at the Early Stage of Primary Infection

Content Provider	Springer Nature Link
Author	Geng, Wenqing Fan, Xuejie Diao, Yingying Cui, Hualu Sun, Hong Yun, Ke Xu, Junjie Zhang, Min Wang, Yanan Zhang, Zining Shang, Hong
Copyright Year	2011
Abstract	To explore the relationship between absolute dendritic cell (DC) counts at the early stage of primary human immunodeficiency virus type 1 (HIV-1) infection (PHI) and subsequent disease progression, we performed a prospective study of 16 rapid progressors (RPs) and 12 typical progressors (TPs) from a PHI cohort of men who have sex with men. Significantly decreased plasmacytoid DC (pDC) and myeloid DC (mDC) counts in the blood of RPs were observed at study entry as compared with TPs and healthy HIV-1-negative subjects. Low baseline pDC counts were significantly associated with rapid disease progression after adjustment for baseline CD4$^{+}$ T cell counts, mDC counts, and HIV-1 load. Kaplan–Meier survival analysis showed that low pDC counts were strongly associated with rapid disease progression. Our findings demonstrated the predictive value of blood absolute pDC counts at baseline in PHI for HIV-1 disease progression. Further studies are required to confirm this notion.
Starting Page	882
Ending Page	890
Page Count	9
File Format	PDF
ISSN	02719142
Journal	Journal of Clinical Immunology
Volume Number	31
Issue Number	5
e-ISSN	15732592
Language	English
Publisher	Springer US
Publisher Date	2011-06-14
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Plasmacytoid dendritic cells myeloid dendritic cells HIV-1 infection immune activation disease progression Medical Microbiology Immunology Internal Medicine Infectious Diseases
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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