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| Content Provider | Springer Nature Link |
|---|---|
| Author | Gunten, Stephan Simon, Hans Uwe |
| Copyright Year | 2010 |
| Abstract | The induction of cell death in immune cells by naturally occurring antibodies specific for death receptors may present an important antiinflammatory mechanism of intravenous immunoglobulin (IVIG). Conversely, the protection of tissue cells from death receptor-mediated apoptosis by blocking antibodies is thought to contribute to the beneficial effects of IVIG in certain inflammatory disorders such as toxic epidermal necrolysis, also known as Lyell's syndrome. In this review, we focus on recent insights into the role of functional antibodies against Fas, sialic acid-binding immunoglobulin-like lectin (Siglec)-8, and Siglec-9 receptors in IVIG-mediated cell survival or death effects. In addition, we examine a variety of factors in inflammatory disease that may interplay with these cellular events and influence the therapeutic efficacy or potency of IVIG. These involve activation status of the target cell, cytokine microenvironment, pathogenesis and stage of disease, individual genetic determinants, species characteristics, and batch-to-batch variations of IVIG preparations. |
| Starting Page | 24 |
| Ending Page | 30 |
| Page Count | 7 |
| File Format | |
| ISSN | 02719142 |
| Journal | Journal of Clinical Immunology |
| Volume Number | 30 |
| Issue Number | 1 |
| e-ISSN | 15732592 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2010-04-20 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Intravenous immunoglobulin IVIG autoimmunity immunoregulation Fas Siglec-8 Siglec-9 Medical Microbiology Internal Medicine Infectious Diseases Immunology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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