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The Natural History of Children with Severe Combined Immunodeficiency: Baseline Features of the First Fifty Patients of the Primary Immune Deficiency Treatment Consortium Prospective Study 6901

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The Natural History of Children with Severe Combined Immunodeficiency: Baseline Features of the First Fifty Patients of the Primary Immune Deficiency Treatment Consortium Prospective Study 6901

Content Provider	Springer Nature Link
Author	Dvorak, Christopher C. Cowan, Morton J. Logan, Brent R. tarangelo, Luigi D. Griffith, Linda M. Puck, Jennifer M. Kohn, Donald B. Shearer, William T. O’Reilly, Richard J. Fleisher, Thomas A. Pai, Sung Yun Hanson, I. Celine Pulsipher, Michael A. Fuleihan, Ramsay Filipovich, Alexandra Goldman, Frederick Kapoor, Neena Small, Trudy Smith, Angela Chan, Ka Wah Cuvelier, Geoff Heimall, Jennifer Knutsen, Alan Loechelt, Brett Moore, Theodore Buckley, Rebecca H.
Copyright Year	2013
Abstract	The Primary Immune Deficiency Treatment Consortium (PIDTC) consists of 33 centers in North America. We hypothesized that the analysis of uniform data on patients with severe combined immunodeficiency (SCID) enrolled in a prospective protocol will identify variables that contribute to optimal outcomes following treatment. We report baseline clinical, immunologic, and genetic features of the first 50 patients enrolled, and the initial therapies administered, reflecting current practice in the diagnosis and treatment of both typical (n = 37) and atypical forms (n = 13) of SCID. From August 2010 to May 2012, patients with suspected SCID underwent evaluation and therapy per local center practices. Diagnostic information was reviewed by the PIDTC eligibility review panel, and hematopoietic cell transplantation (HCT) details were obtained from the Center for International Blood and Marrow Transplant Research. Most patients (92 %) had mutations in a known SCID gene. Half of the patients were diagnosed by newborn screening or family history, were younger than those diagnosed by clinical signs (median 15 vs. 181 days; P = <0.0001), and went to HCT at a median of 67 days vs. 214 days of life (P = <0.0001). Most patients (92 %) were treated with HCT within 1–2 months of diagnosis. Three patients were treated with gene therapy and 1 with enzyme replacement. The PIDTC plans to enroll over 250 such patients and analyze short and long-term outcomes for factors beneficial or deleterious to survival, clinical outcome, and T- and B-cell reconstitution, and which biomarkers are predictive of these outcomes.
Starting Page	1156
Ending Page	1164
Page Count	9
File Format	PDF
ISSN	02719142
Journal	Journal of Clinical Immunology
Volume Number	33
Issue Number	7
e-ISSN	15732592
Language	English
Publisher	Springer US
Publisher Date	2013-07-02
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Severe combined immunodeficiency hematopoietic cell transplantation newborn screening Immunology Infectious Diseases Internal Medicine Medical Microbiology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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The Natural History of Children with Severe Combined Immunodeficiency: Baseline Features of the First Fifty Patients of the Primary Immune Deficiency Treatment Consortium Prospective Study 6901

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