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| Content Provider | Springer Nature Link |
|---|---|
| Author | Wong, C. K. Wong, Purple T. Y. Tam, L. S. Li, Edmund K. Chen, D. P. Lam, Christopher W. K. |
| Copyright Year | 2009 |
| Abstract | B lymphocyte chemoattractant (BLC/CXCL13), a CXC chemokine, is involved in B1 and B2 cell trafficking for the activation of autoreactive T helper (Th) cells and autoantibody production in target organs during the development of lupus. CXCL13 can induce the trafficking of CXCR5+ T lymphocyte subset designated as follicular helper T lymphocytes (T$_{FH}$) which are specifically involved in autoantibody production.We herein measured the plasma concentrations of CXCL13, B-cell-activating factor of the TNF family (BAFF), and T$_{FH}$-cells-related cytokine IL-21 and cell surface expression of T$_{FH}$-related receptor CXCR5 and IL-21R on CD4+Th and CD19+B cells in 35 systemic lupus erythematosus (SLE) patients and 23 sex- and age-matched control subjects (NC) using enzyme-linked immunosorbent assay and flow cytometry, respectively.Plasma CXCL13, BAFF, and IL-21 concentrations were significantly higher in SLE patients than NC group (all p < 0.0001). Increase in CXCL13 concentration correlated positively and significantly with SLEDAI score in SLE patients (r = 0.399, p = 0.032). Cell surface expression of CXCR5 on Th and B cells and IL-21R on B cells was however significantly lower in SLE patients than controls (both p < 0.01). It may indicate that most differentiated T$_{FH}$ cells migrate out from circulation into lymphoid organ upon activation during the disease development of SLE.The above results suggest that the elevated production of CXCL13, BAFF, and IL-21 may be associated with the function of T$_{FH}$ for the immunopathogenesis in SLE, and CXCL13 may serve as a potential disease marker of SLE. |
| Starting Page | 45 |
| Ending Page | 52 |
| Page Count | 8 |
| File Format | |
| ISSN | 02719142 |
| Journal | Journal of Clinical Immunology |
| Volume Number | 30 |
| Issue Number | 1 |
| e-ISSN | 15732592 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2009-09-23 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | B cells B-cell-activating factor of the TNF family chemokines CXCL13 follicular helper T lymphocytes systemic lupus erythematosus Medical Microbiology Internal Medicine Infectious Diseases Immunology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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