NDLI: RANTES Deficiency Attenuates Autoantibody-Induced Glomerulonephritis

Content Provider	Springer Nature Link
Author	Xie, Chun Liu, Kui Fu, Yuyang Qin, Xiangmei Jonnala, Geetha Wang, Tao Wang, Hong W. Maldonado, Michael Zhou, Xin J. Mohan, Chandra
Copyright Year	2010
Abstract	Experimental autoimmune nephritis in mice and spontaneous lupus nephritis are both associated with elevated expression of several chemokines in the kidneys. Nevertheless, the role that different chemokines play in mediating renal inflammation is far from complete. This study focuses on elucidating the functional role of RANTES, a chemokine that has been noted to be hyper-expressed within the kidneys, both in experimental renal disease as well as in spontaneous lupus nephritis. To elucidate if RANTES was essential for immune-mediated glomerulonephritis, DBA/1 mice that are highly sensitive to nephrotoxic serum nephritis were rendered RANTES-deficient and then tested for disease susceptibility. Nephritis-sensitive DBA/1 mice expressed more RANTES within the diseased kidneys. Compared to wild-type DBA/1 mice, RANTES-deficient DBA/1 mice developed significantly less proteinuria, azotemia, and renal inflammation, with reduced crescent formation and tubulo-interstitial nephritis. These findings indicate that RANTES ablation attenuates immune-mediated nephritis and suggest that this chemokine could be a potential therapeutic target in these diseases.
Starting Page	128
Ending Page	135
Page Count	8
File Format	PDF
ISSN	02719142
Journal	Journal of Clinical Immunology
Volume Number	31
Issue Number	1
e-ISSN	15732592
Language	English
Publisher	Springer US
Publisher Date	2010-10-01
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	RANTES DBA/1 lupus genetics Immunology Medical Microbiology Infectious Diseases Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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