NDLI: Genetic Association of IL-10 Gene Promoter Polymorphism and HIV-1 Infection in North Indians

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Genetic Association of IL-10 Gene Promoter Polymorphism and HIV-1 Infection in North Indians

Content Provider	Springer Nature Link
Author	Chatterjee, Animesh Rathore, Anurag Sivarama, P. Yamamoto, Naohiko Dhole, Tapan N.
Copyright Year	2008
Abstract	Cytokines play a significant role in host immune defense. IL-10 is an anti-inflammatory, immunomodulatory cytokine that can both stimulate and suppress the immune response and inhibits HIV-1 replication in vivo. Interindividual variations in IL-10 production were genetically contributed to polymorphisms within IL-10 promoter region.The aim of this study was to investigate the association of IL-10 gene promoter −1082 G/A, −819 C/T, and 592 C/A polymorphism on HIV-1 transmission /progression in North Indian individuals.A total of 180 HIV-1 seropositive (HSP) stratified on the basis of disease severity (stage I, II, and III), 50 HIV-1 exposed seronegative (HES) and 305 HIV-1 seronegative (HSN) individuals were genotyped for IL-10 gene promoter by polymerase chain reaction-restriction fragment length polymorphism. A suggestive evidence of association was obtained for IL-10 592 C/A promoter polymorphism at the level of allele and genotype distribution. The frequency of IL-10 592 A allele and genotype was significantly increased in HSP compared to HSN (p = 0.013; OR = 1.412 and p = 0.034; OR = 1.685 respectively). Further comparison in between different clinical stages of HIV-1 infected patients of IL-10 592 A allele and genotype revealed a significant increase in its frequency in the stage III compared with those together in stage I (p = 0.004, OR = 2.181 and p = 0.002, OR = 4.156, respectively). This study reports for the first time that IL-10 gene promoter 592 C/A polymorphism may be a risk factor for HIV-1 transmission/progression in HIV-1 infected North Indian individuals.
Starting Page	71
Ending Page	77
Page Count	7
File Format	PDF
ISSN	02719142
Journal	Journal of Clinical Immunology
Volume Number	29
Issue Number	1
e-ISSN	15732592
Language	English
Publisher	Springer US
Publisher Date	2008-08-06
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Interleukin promoter polymorphism HIV/AIDS transmission progression Medical Microbiology Internal Medicine Infectious Diseases Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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