NDLI: Immune Reconstitution and Viral Stimulation Are Required to Restore HIV-Specific CD8 T Cell Responses Following Advanced Infection

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Journal of Clinical Immunology : Volume 24, Issue 1, January 2004

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Immune Reconstitution and Viral Stimulation Are Required to Restore HIV-Specific CD8 T Cell Responses Following Advanced Infection

Content Provider	Springer Nature Link
Author	Gamberg, Jane Barrett, Lisa Bowmer, Ian Howley, Constance Grant, Michael
Copyright Year	2004
Abstract	The extent to which highly active antiretroviral therapy (HAART) restores human immunodeficiency virus (HIV)-specific immunity in advanced infection is unknown. Therefore, we studied how effective therapy affected HIV-specific CD8$^{+}$ T cell responses in 4 individuals who had progressed to advanced infection. CD8$^{+}$ T cell responses were assessed by cytotoxicity and interferon-gamma (IFN-γ) production. Proliferative CD4$^{+}$ T cell responses against HIV, Candida and mitogen were measured by $^{3}$H-thymidine incorporation. Substantial immune reconstitution indicated by increased CD4$^{+}$ and CD8$^{+}$ T cell numbers followed suppression of viral replication. This was associated with emergence of HIV-specific cytotoxic T lymphocytes (CTL), but only concurrent with detectable viral replication. Emergent anti-HIV CTL were similar to those at earlier stages of infection in terms of their specificity, function, and CD28 phenotype. However, they were very short-lived in the absence of detectable HIV replication. Antigen-specific CD4$^{+}$ T cell responses remained severely compromised. Thus, effective antiretroviral therapy restores the capacity for HIV-specific CTL responses after advanced infection. However, the transient nature of these responses suggests failure to generate stable long-lived memory cells in the absence of HIV-specific helper T cell responses.
Starting Page	115
Ending Page	124
Page Count	10
File Format	PDF
ISSN	02719142
Journal	Journal of Clinical Immunology
Volume Number	24
Issue Number	2
e-ISSN	15732592
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2004-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Immunology Medical Microbiology Internal Medicine Infectious Diseases
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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