NDLI: Effects of CD70 and CD11a in Immune Thrombocytopenia Patients

Content Provider	Springer Nature Link
Author	Ma, Li Zhou, Zeping Jia, Hairong Zhou, Hu Qi, Aiping Li, Huiyuan Wang, Hongmei Zhang, Lei Yang, Renchi
Copyright Year	2011
Abstract	CD70 and CD11a are co-stimulatory molecules that are important for the immune functions of T, B lymphocytes. Over-expressions of CD70 or CD11a cause T cell to be autoreactive.The purpose of this study was to explore the effect of CD70 and CD11a in immune thrombocytopenia (ITP).CD70 and CD11a mRNAs and protein expressions in CD4$^{+}$ T cells from ITP patients were measured respectively by real-time quantitative-PCR (RT-PCR) and flow cytometry. The apoptosis of T cells, B cells, and platelets in the PBMCs were analyzed by flow cytometry, and secretion of IL-4, IFN-γ, as well as IgG in the reaction supernatant were detected by ELISA. In order to investigate the effects of CD70 and CD11a over-expression on pathogenesis of ITP, anti-CD70, and anti-CD11a mAbs were used to block the signaling pathways.CD70 and CD11a mRNAs and protein expressions in CD4$^{+}$ T cells from ITP patients were significantly higher than healthy controls. In vitro co-culturing of PBMCs with anti-CD70 or anti-CD11a, the apoptosis of T, B lymphocytes were significantly increased but apoptosis of platelets were reduced. Anti-CD11a and anti-CD70 both significantly suppressed the secretion of IFN-γ, while anti-CD11a significantly promoted the secretion of IL-4. There was no significant difference in the healthy group.CD70 and CD11a facilitate the survival of T, B lymphocytes and indirectly enhance the destruction of platelets in ITP. Blockade of CD70 or CD11a are promising therapeutic approaches for ITP.
Starting Page	632
Ending Page	642
Page Count	11
File Format	PDF
ISSN	02719142
Journal	Journal of Clinical Immunology
Volume Number	31
Issue Number	4
e-ISSN	15732592
Language	English
Publisher	Springer US
Publisher Date	2011-05-04
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	ITP B cells T cells platelets autoimmune diseases apoptosis Infectious Diseases Immunology Medical Microbiology Internal Medicine
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Bmi-1 Regulates Autoreactive CD4$^{+}$ T Cell Survival in Immune Thrombocytopenia Patients

Elevated Interleukin-21 Correlated to Th17 and Th1 Cells in Patients with Immune Thrombocytopenia

Pathogenesis and Therapeutic Mechanisms in Immune Thrombocytopenia (ITP)

Pulsed High-dose Dexamethasone Improves Interleukin 10 Secretion by CD5$^{+}$ B Cells in Patients with Primary Immune Thrombocytopenia

Multiple Sclerosis and Regulatory T Cells

Telomerase Activity Increased and Telomere Length Shortened in Peripheral Blood Cells from Patients with Immune Thrombocytopenia

High-Dose Dexamethasone Inhibits BAFF Expression in Patients with Immune Thrombocytopenia

Immune Aberrations in B and T Lymphocytes Derived from Chronic Urticaria Patients

A Rapid Ex Vivo Clinical Diagnostic Assay for Fas Receptor-Induced T Lymphocyte Apoptosis

Effects of CD70 and CD11a in Immune Thrombocytopenia Patients

Similar Documents

Bmi-1 Regulates Autoreactive CD4$^{+}$ T Cell Survival in Immune Thrombocytopenia Patients

Elevated Interleukin-21 Correlated to Th17 and Th1 Cells in Patients with Immune Thrombocytopenia

Pathogenesis and Therapeutic Mechanisms in Immune Thrombocytopenia (ITP)

Pulsed High-dose Dexamethasone Improves Interleukin 10 Secretion by CD5$^{+}$ B Cells in Patients with Primary Immune Thrombocytopenia

Multiple Sclerosis and Regulatory T Cells

Telomerase Activity Increased and Telomere Length Shortened in Peripheral Blood Cells from Patients with Immune Thrombocytopenia

High-Dose Dexamethasone Inhibits BAFF Expression in Patients with Immune Thrombocytopenia

Immune Aberrations in B and T Lymphocytes Derived from Chronic Urticaria Patients

A Rapid Ex Vivo Clinical Diagnostic Assay for Fas Receptor-Induced T Lymphocyte Apoptosis

Effects of CD70 and CD11a in Immune Thrombocytopenia Patients