NDLI: Characterization of the Impaired Antipneumococcal Polysaccharide Antibody Production in Immunosuppressed Pediatric Patients Following Cardiac Transplantation

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Characterization of the Impaired Antipneumococcal Polysaccharide Antibody Production in Immunosuppressed Pediatric Patients Following Cardiac Transplantation

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Characterization of the Impaired Antipneumococcal Polysaccharide Antibody Production in Immunosuppressed Pediatric Patients Following Cardiac Transplantation

Content Provider	Springer Nature Link
Author	Gennery, A. R. Cant, A. J. Baldwin, C. I. Calvert, J. E.
Copyright Year	2001
Abstract	We previously have demonstrated impaired pneumococcal polysaccharide IgG antibody responses in children immunosuppressed following cardiac transplantation in early childhood. We have further characterized the antibody defect. To further investigate the production of antibody, anti-pneumococcal polysaccharide (PPS) specific IgM, IgG, IgG subclasses, and IgA were measured in postvaccination sera by enzyme-linked immunosorbent assay. Two groups were studied: posttransplant children who made pneumococcal antibody in vivo following natural exposure or PPS immunization (R) and those with an impaired response (NR).There was no difference in IgM or IgA levels between R and NR. IgG and IgG2 levels were higher in R than NR (P = 0.002), even after adsorption of nonspecific common cell wall antigen antibody. Differences in anti-pneumococcal antibody levels suggest that immunoglobulin isotype switching from IgM to IgG and particularly IgG2 is impaired in patients immunosuppressed at a young age. These findings confirm data regarding the effect of immunosuppressive agents derived from animal models in humans.
Starting Page	43
Ending Page	50
Page Count	8
File Format	PDF
ISSN	02719142
Journal	Journal of Clinical Immunology
Volume Number	21
Issue Number	1
e-ISSN	15732592
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2001-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Immunology Medical Microbiology Internal Medicine Infectious Diseases
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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