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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ying, Tianlei Zhong, Fangfang Xie, Jin Feng, Yanjiao Wang, Zhong Hua Huang, Zhong Xian Tan, Xiangshi |
| Copyright Year | 2009 |
| Abstract | Conformational transitions in cytochrome c (cyt c) are being realized to be responsible for its multi-functions. Among a number of conformational transitions in cyt c, the alkaline transition has attracted much attention. The cDNA of human cyt c is cloned by RT-PCR and a high-effective expression system for human cyt c has been developed in this study. The equilibrium and kinetics of the alkaline transition of human cyt c have been systematically investigated for the first time, and compared with those of yeast and horse cyt c from an evolutionary perspective. The pK$_{a}$ value for the alkaline transition of human cyt c is apparently higher than that of yeast and horse. Kinetic studies suggest that it is increasingly difficult for the alkaline transition of cyt c from yeast, horse and human. Molecular modeling of human cyt c shows that the omega loop where the lysine residue is located apparently further away from heme in human cyt c than in yeast iso-1 and horse heart cyt c. These results regarding alkaline conformational transition provide valuable information for understanding the molecular basis for the biological multi-functions of cyt c. |
| Starting Page | 251 |
| Ending Page | 257 |
| Page Count | 7 |
| File Format | |
| ISSN | 0145479X |
| Journal | Journal of Bioenergetics and Biomembranes |
| Volume Number | 41 |
| Issue Number | 3 |
| e-ISSN | 15736881 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2009-07-11 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Human cytochrome c Alkaline transition pH-jump Organic Chemistry Animal Biochemistry Animal Anatomy / Morphology / Histology Biochemistry Bioorganic Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Physiology |
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