NDLI: Cooperation of a “Reactive Oxygen Cycle” with The Q Cycle and The Proton Cycle in the Respiratory Chain—Superoxide Generating and Cycling Mechanisms in Mitochondria

Content Provider	Springer Nature Link
Author	Liu, Shu sen
Copyright Year	1999
Abstract	Based on our recent findings concerning the generating, partitioning, targeting, and functioningof superoxide in mitochondria, a hypothetical model involving a “reactive oxygen cycle” inthe respiratory chain has been proposed (Liu and Huang, 1991, 1996; Liu et al., 1996; Liu,1997, 1998) This model emphasizes that during State 4 respiration, an interaction between anelectron leak (a branch of electron transfer directly from the respiratory chain to form O$^{•-}$ $_{2}$,but not H$_{2}$O) and a proton leak (a branch pathway which utilizes $$\Delta \mu _{{\text{H}}^{\text{ + }} } $$ to produce heat, butnot ATP) may take place in cooperation with the Q and proton cycles in mitochondria throughthe consumption of H$^{+}$ by O$^{•-}$ $_{2}$ anions to form a protonated perhydroxyl radical, HO$_{2}$, whichis directly permeable across the inner mitochondrial membrane and induces proton leakageand a decrease of $$\Delta \mu _{{\text{H}}^{\text{ + }} } $$ . O$^{•-}$ $_{2}$ generation in the mitochondrial respiratory chain and its cyclingacross the inner membrane may have the role of an endogenous protonophore in regulating andpartitioning energy transduction and heat production, as well as in pathogenesis of mitochondrialdiseases, aging, and apoptosis. The present article summarizes the supporting experimentalevidence obtained in this laboratory and presents a brief description of the theoretical basisof this model
Starting Page	367
Ending Page	376
Page Count	10
File Format	PDF
ISSN	0145479X
Journal	Journal of Bioenergetics and Biomembranes
Volume Number	31
Issue Number	4
e-ISSN	15736881
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	1999-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Organic Chemistry Biochemistry Animal Biochemistry Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology

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