NDLI: Trans,trans-2,4-decadienal induces mitochondrial dysfunction and oxidative stress

Content Provider	Springer Nature Link
Author	Sigolo, Carlos A. O. Di Mascio, Paolo Kowaltowski, Alicia J. Garcia, Camila C. M. Medeiros, Marisa H. G.
Copyright Year	2008
Abstract	Lipid peroxidation produces a large number of reactive aldehydes as secondary products. We have previously shown that the reaction of cytochrome c with trans,trans-2,4-decadienal (DDE), an aldehyde generated as a product of lipid peroxidation in cell membranes, results in the formation of adducts. Mass spectrometry analysis indicated that His-33, Lys-39, Lys-72 and Lys-100 in cytochrome c were modified by DDE. In the present work, we investigated the effect of DDE on isolated rat liver mitochondria. DDE (162 μM) treatment increases the rate of mitochondrial oxygen consumption. Extensive mitochondrial swelling upon treatment with DDE (900 nM–162 μM) was observed by light scattering and transmission electron microscopy experiments. DDE-induced loss of inner mitochondrial membrane potentials, monitored by safranin O fluorescence, was also observed. Furthermore, DDE-treated mitochondria showed an increase in lipid peroxidation, as monitored by MDA formation. These results suggest that reactive aldehydes promote mitochondrial dysfunction.
Starting Page	103
Ending Page	109
Page Count	7
File Format	PDF
ISSN	0145479X
Journal	Journal of Bioenergetics and Biomembranes
Volume Number	40
Issue Number	2
e-ISSN	15736881
Language	English
Publisher	Springer US
Publisher Date	2008-03-27
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	DDE Mitochondria Lipid peroxidation Mitochondrial swelling Organic Chemistry Animal Biochemistry Animal Anatomy / Morphology / Histology Biochemistry Bioorganic Chemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology

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