NDLI: Mitochondria in Ca2+ Signaling and Apoptosis

Content Provider	Springer Nature Link
Author	Smaili, Soraya S. Hsu, Yi Te Youle, Richard J. Russell, James T.
Copyright Year	2000
Abstract	Cellular Ca$^{2+}$ signals are crucial in the control of most physiological processes, cell injuryand programmed cell death; mitochondria play a pivotal role in the regulation of such cytosolicCa$^{2+}$ ([Ca$^{2+}$]$_{c}$) signals. Mitochondria are endowed with multiple Ca$^{2+}$ transport mechanismsby which they take up and release Ca$^{2+}$ across their inner membrane. These transport processesfunction to regulate local and global [Ca$^{2+}$]$_{c}$, thereby regulating a number of Ca$^{2+}$-sensitivecellular mechanisms. The permeability transition pore (PTP) forms the major Ca$^{2+}$ effluxpathway from mitochondria. In addition, Ca$^{2+}$ efflux from the mitochondrial matrix occursby the reversal of the uniporter and through the inner membrane Na$^{+}$/Ca$^{2+}$ exchanger. Duringcellular Ca$^{2+}$ overload, mitochondria take up [Ca$^{2+}$]$_{c}$, which, in turn, induces opening of PTP,disruption of mitochondrial membrane potential (ΔΨ$_{m}$) and cell death. In apoptosis signaling,collapse of ΔΨ;$_{m}$ and cytochrome c release from mitochondria occur followed by activationof caspases, DNA fragmentation, and cell death. Translocation of Bax, an apoptotic signalingprotein from the cytosol to the mitochondrial membrane, is another step during thisapoptosis-signaling pathway. The role of permeability transition in the context of cell death in relationto Bcl-2 family of proteins is discussed.
Starting Page	35
Ending Page	46
Page Count	12
File Format	PDF
ISSN	0145479X
Journal	Journal of Bioenergetics and Biomembranes
Volume Number	32
Issue Number	1
e-ISSN	15736881
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2000-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Organic Chemistry Biochemistry Animal Biochemistry Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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