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| Content Provider | Springer Nature Link |
|---|---|
| Author | Park, Si Nae Jang, Han Jeong Choi, Yu Suk Cha, Jae Min Son, Seo Yeon Han, Seung Hun Kim, Jung Hyun Lee, Woo Jung Suh, Hwal |
| Copyright Year | 2007 |
| Abstract | Postoperative adhesions remain a significant complication of abdominal surgery although the wide variety of physical barriers has been developed to reduce the incidence of adhesion. In this study, the bilayered composite membrane formed by the association of a methoxy poly (ethylene glycol)-poly (L-lactide-co-glycolide) (mPEG-PLGA) film and a crosslinked collagen-hyaluronic acid (Col-HA) membrane with fibronectin (FN) coating was prepared for promoting wound healing and providing tissue adhesion resistance simultaneously. In vitro adhesion test revealed that fibroblasts attached better on Col-HA membrane compared to those on mPEG-PLGA film, PLGA film or Interceed$^{TM}$ (oxidized cellulose) while mPEG-PLGA film had the lowest cell adhesive property. In confocal microscopic observation, the actin filaments were significantly further polymerized when 50 or 100 μg/cm$^{3}$ fibronectin was incorporated on the COL-HA membranes. After 7-day culture, fibroblasts penetrated throughout the Col-HA-FN network and the cell density increased whereas very few cells were found attached on the surface of the mPEG-PLGA film. In vivo evaluation test showed that the composite membrane could remain during the critical period of peritoneal healing and did not provoke any inflammation or adverse tissue reaction. |
| Starting Page | 475 |
| Ending Page | 482 |
| Page Count | 8 |
| File Format | |
| ISSN | 09574530 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume Number | 18 |
| Issue Number | 3 |
| e-ISSN | 15734838 |
| Language | English |
| Publisher | Kluwer Academic Publishers |
| Publisher Date | 2007-01-01 |
| Publisher Place | Boston |
| Access Restriction | Subscribed |
| Subject Keyword | Biomaterials Characterization and Evaluation of Materials Polymer Sciences Metallic Materials Ceramics, Glass, Composites, Natural Methods Surfaces and Interfaces, Thin Films |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biophysics Bioengineering Biomedical Engineering |
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