NDLI: In vitro blood and fibroblast responses to BisGMA–TEGDMA/bioactive glass composite implants

Content Provider	Springer Nature Link
Author	Abdulmajeed, Aous A. Kokkari, Anne K. Käpylä, Jarmo Massera, Jonathan Hupa, Leena Vallittu, Pekka K. Närhi, Timo O.
Copyright Year	2013
Abstract	This in vitro study was designed to evaluate both blood and human gingival fibroblast responses to bisphenol A–glycidyl methacrylate–triethyleneglycol dimethacrylate (BisGMA–TEGDMA)/bioactive glass (BAG) composite, aimed to be used as composite implant abutment surface modifier. Three different types of substrates were investigated: (a) plain polymer (BisGMA 50 wt%–TEGDMA 50 wt%), (b) BAG–composite (50 wt% polymer + 50 wt% fraction of BAG–particles, <50 μm), and (c) plain BAG plates (100 wt% BAG). The blood response, including the blood–clotting ability and platelet adhesion morphology were evaluated. Human gingival fibroblasts were plated and cultured on the experimental substrates for up to 10 days, then the cell proliferation rate was assessed using AlamarBlue assay™. The BAG–composite and plain BAG substrates had a shorter clotting time than plain polymer substrates. Platelet activation and aggregation were most extensive, qualitatively, on BAG–composite. Analysis of the normalized cell proliferation rate on the different surfaces showed some variations throughout the experiment, however, by day 10 the BAG–composite substrate showed the highest (P < 0.001) cell proliferation rate. In conclusion, the presence of exposed BAG–particles enhances fibroblast and blood responses on composite surfaces in vitro.
Starting Page	151
Ending Page	162
Page Count	12
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	25
Issue Number	1
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2013-09-11
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Biomaterials Polymer Sciences Ceramics, Glass, Composites, Natural Methods Metallic Materials Characterization and Evaluation of Materials Surfaces and Interfaces, Thin Films
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Bioactive glass induced in vitro apatite formation on composite GBR membranes

Osteoblast response to polymethyl methacrylate bioactive glass composite

In vitro behaviour of three biocompatible glasses in composite implants

Chitosan composite films. Biomedical applications

Bioactive borosilicate glass scaffolds: in vitro degradation and bioactivity behaviors

Gene activation by bioactive glasses

Macroporous bioactive glass-ceramic scaffolds for tissue engineering

Bioactive borate glass coatings for titanium alloys

In vivo evaluation of titanium implants coated with bioactive glass by pulsed laser deposition

In vitro blood and fibroblast responses to BisGMA–TEGDMA/bioactive glass composite implants

Similar Documents

Bioactive glass induced in vitro apatite formation on composite GBR membranes

Osteoblast response to polymethyl methacrylate bioactive glass composite

In vitro behaviour of three biocompatible glasses in composite implants

Chitosan composite films. Biomedical applications

Bioactive borosilicate glass scaffolds: in vitro degradation and bioactivity behaviors

Gene activation by bioactive glasses

Macroporous bioactive glass-ceramic scaffolds for tissue engineering

Bioactive borate glass coatings for titanium alloys

In vivo evaluation of titanium implants coated with bioactive glass by pulsed laser deposition

In vitro blood and fibroblast responses to BisGMA–TEGDMA/bioactive glass composite implants