NDLI: In vitro and in vivo evaluation of the biocompatibility of a calcium phosphate/poly(lactic-co-glycolic acid) composite

Content Provider	Springer Nature Link
Author	Gala García, A. Carneiro, M. B. H. Silva, G. A. B. Ferreira, L. S. Vieira, L. Q. Marques, M. M. Sinisterra, R. D. Cortes, M. E.
Copyright Year	2012
Abstract	This study assess the effects of bioceramic and poly(lactic-co-glycolic acid) composite (BCP/PLGA) on the viability of cultured macrophages and human dental pulp fibroblasts, and we sought to elucidate the temporal profile of the reaction of pulp capping with a composite of bioceramic of calcium phosphate and biodegradable polymer in the progression of delayed dentine bridge after (30 and 60 days) in vivo. Histological evaluation of inflammatory infiltrate and dentin bridge formation were performed after 30 and 60 days. There was similar progressive fibroblast growth in all groups and the macrophages showed viability. The in vivo study showed that of the three experimental groups: BCP/PLGA composite, BCP and calcium hydroxide (Ca(OH)$_{2}$) dentin bridging was the most prevalent (90 %) in the BCP/PLGA composite after 30 days, mild to moderate inflammatory response was present throughout the pulp after 30 days. After 60 days was observed dentine bridging in 60 % and necrosis in 40 %, in both groups. The results indicate that understanding BCP/PLGA composite is biocompatible and by the best tissue response as compared to calcium hydroxide in direct pulp capping may be important in the mechanism of delayed dentine bridge after 30 and 60 days.
Starting Page	1785
Ending Page	1796
Page Count	12
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	23
Issue Number	7
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2012-05-09
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Ceramics, Glass, Composites, Natural Methods Biomaterials Characterization and Evaluation of Materials Polymer Sciences Surfaces and Interfaces, Thin Films Metallic Materials
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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