NDLI: A novel bioactive porous bredigite (Ca$_{7}$MgSi$_{4}$O$_{16}$) scaffold with biomimetic apatite layer for bone tissue engineering

Content Provider	Springer Nature Link
Author	Wu, Chengtie Chang, Jiang Zhai, Wanyin Ni, Siyu
Copyright Year	2007
Abstract	The aim of this study was to develop a novel bioactive, degradable and cytocompatible bredigite (Ca$_{7}$MgSi$_{4}$O$_{16}$) scaffold with biomimetic apatite layer for bone tissue engineering. Porous bredigite scaffolds were prepared using polymer sponge method. The bredigite scaffolds with biomimetic apatite layer (BTAP) were obtained by soaking bredigite scaffolds in simulated body fluid (SBF) for 10 days. The porosity and in vitro degradability of BTAP scaffolds were investigated. In addition, osteoblast-like cell morphology, proliferation and differentiation on BTAP scaffolds were evaluated and compared with β-tricalcium phosphate (β-TCP) scaffolds. The results showed that BTAP scaffolds possessed 90% of porosity. The degradation of BTAP scaffolds was comparable to that of β-TCP scaffolds. Cells on BTAP scaffolds spread well and presented a higher proliferation rate and differentiation level as compared with those on β-TCP scaffolds. Our results indicated that BTAP scaffolds were degradable and possessed the function to enhance cell proliferation and differentiation, and might be used as bone tissue engineering materials.
Starting Page	857
Ending Page	864
Page Count	8
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	18
Issue Number	5
e-ISSN	15734838
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2007-01-09
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Surfaces and Interfaces, Thin Films Ceramics, Glass, Composites, Natural Methods Metallic Materials Polymer Sciences Characterization and Evaluation of Materials Biomaterials
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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