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| Content Provider | Springer Nature Link |
|---|---|
| Author | Gustavsson, Johan Altankov, George Errachid, Abdelhamid Samitier, Josep Planell, Josep A. Engel, Elisabeth |
| Copyright Year | 2008 |
| Abstract | Thin films of silicon nitride (Si$_{3}$N$_{4}$) can be used in several kinds of micro-sized biosensors as a material to monitor fine environmental changes related to the process of bone formation in vitro. We found however that Si$_{3}$N$_{4}$ does not provide optimal conditions for osseointegration as osteoblast-like MG-63 cells tend to detach from the surface when cultured over confluence. Therefore Si$_{3}$N$_{4}$ was modified with self-assembled monolayers bearing functional end groups of primary amine (NH$_{2}$) and carboxyl (COOH) respectively. Both these modifications enhanced the interaction with confluent cell layers and thus improve osseointegration over Si$_{3}$N$_{4}$. Furthermore it was observed that the NH$_{2}$ functionality increased the adsorption of fibronectin (FN), promoted cell proliferation, but delayed the differentiation. We also studied the fate of pre-adsorbed and secreted FN from cells to learn more about the impact of above functionalities for the development of provisional extracellular matrix on materials interface. Taken together our data supports that Si$_{3}$N$_{4}$ has low tissue integration but good cellular biocompatibility and thus is appropriate in cellular biosensor applications such as the ion-sensitive field effect transistor (ISFET). COOH and NH$_{2}$ chemistries generally improve the interfacial tissue interaction with the sensor and they are therefore suitable substrates for monitoring cellular growth or matrix deposition using electrical impedance spectroscopy. |
| Starting Page | 1839 |
| Ending Page | 1850 |
| Page Count | 12 |
| File Format | |
| ISSN | 09574530 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume Number | 19 |
| Issue Number | 4 |
| e-ISSN | 15734838 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2008-01-25 |
| Publisher Place | Boston |
| Access Restriction | Subscribed |
| Subject Keyword | Surfaces and Interfaces, Thin Films Ceramics, Glass, Composites, Natural Methods Metallic Materials Polymer Sciences Characterization and Evaluation of Materials Biomaterials |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biophysics Bioengineering Biomedical Engineering |
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