NDLI: Hyaluronan based porous nano-particles enriched with growth factors for the treatment of ulcers: a placebo-controlled study

Content Provider	Springer Nature Link
Author	Zavan, B. Vindigni, V. Vezzù, K. Zorzato, G. Luni, C. Abatangelo, G. Elvassore, N. Cortivo, R.
Copyright Year	2008
Abstract	The present study describes the production of hyaluronan based porous microparticles by a semi-continuous gas anti-solvent (GAS) precipitation process to be used as a growth factor delivery system for in vivo treatment of ulcers. Operative process conditions, such as pressure, nozzle diameter and HYAFF11$^{®}$ solution concentrations, were adjusted to optimize particle production in terms of morphology and size. Scanning electron microscopy (SEM) and light scattering demonstrated that porous nano-structured particles with a size of 300 and 900 nm had a high specific surface suitable for absorption of growth factors from the aqueous environment within the polymeric matrix. Water acted as a plasticizer, enhancing growth factor absorption. Water contents within the HYAFF11$^{®}$ matrix were analyzed by differential scanning calorimetry (DSC). The absorption process was developed using fluorescence dyes and growth factors. Immunohistochemical analysis confirmed the high efficiency of absorption of growth factor and a mathematical model was generated to quantify and qualify the in vitro kinetics of growth factor release within the polymeric matrix. In vivo experiments were performed with the aim to optimize timed and focal release of PDGF to promote optimal tissue repair and regeneration of full-thickness wounds.
Starting Page	235
Ending Page	247
Page Count	13
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	20
Issue Number	1
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2008-08-30
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Surfaces and Interfaces, Thin Films Characterization and Evaluation of Materials Metallic Materials Ceramics, Glass, Composites, Natural Methods Polymer Sciences Biomaterials
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Characterization of and host response to tyramine substituted-hyaluronan enriched fascia extracellular matrix

Erratum to: Characterization of and host response to tyramine substituted-hyaluronan enriched fascia extracellular matrix

Synthesis and characterization of tyramine-based hyaluronan hydrogels

Porous polymer/hydroxyapatite scaffolds: characterization and biocompatibility investigations

A novel hydrogel crosslinked hyaluronan with glycol chitosan

Novel electrohydrodynamic preparation of porous chitosan particles for drug delivery

Evaluation of 3D nano–macro porous bioactive glass scaffold for hard tissue engineering

Preparation and characterization of nano-hydroxyapatite/polymer composite scaffolds

Development of nano-macroporous soda-lime phosphofluorosilicate bioactive glass and glass-ceramics

Hyaluronan based porous nano-particles enriched with growth factors for the treatment of ulcers: a placebo-controlled study

Similar Documents

Characterization of and host response to tyramine substituted-hyaluronan enriched fascia extracellular matrix

Erratum to: Characterization of and host response to tyramine substituted-hyaluronan enriched fascia extracellular matrix

Synthesis and characterization of tyramine-based hyaluronan hydrogels

Porous polymer/hydroxyapatite scaffolds: characterization and biocompatibility investigations

A novel hydrogel crosslinked hyaluronan with glycol chitosan

Novel electrohydrodynamic preparation of porous chitosan particles for drug delivery

Evaluation of 3D nano–macro porous bioactive glass scaffold for hard tissue engineering

Preparation and characterization of nano-hydroxyapatite/polymer composite scaffolds

Development of nano-macroporous soda-lime phosphofluorosilicate bioactive glass and glass-ceramics

Hyaluronan based porous nano-particles enriched with growth factors for the treatment of ulcers: a placebo-controlled study