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| Content Provider | Springer Nature Link |
|---|---|
| Author | Studevská, Hana Šlouf, Miroslav Rypáček, František |
| Copyright Year | 2007 |
| Abstract | The technique for fabrication of soft porous hydrogels, in which both the size and the orientation of inner pores can be controlled, was developed. Three-dimensional hydrophilic gels based on poly[2-hydroxyethyl methacrylate] are designed as scaffolds for regeneration of soft tissues, e.g., nerve tissue. Anisotropic macropores of the size ranging from 10 to 50 μm were formed (1) by using a porogen-leaching method with a solid organic porogen, (2) by phase-separation during gelation in solvent-nonsolvent mixture, or (3) by combination of solid porogen elimination and phase-separation. As a porogen, poly(l-lactide) fibers were applied and consequently washed away under mild conditions to obtain desired spatial orientation of pores. Highly water-swollen polymer gels were characterized with high pressure (low vacuum) scanning electron microscopy (AquaSEM). The morphology of voids remaining after removing the solid PLLA porogen (the macropores) was clearly shown. |
| Starting Page | 615 |
| Ending Page | 621 |
| Page Count | 7 |
| File Format | |
| ISSN | 09574530 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume Number | 19 |
| Issue Number | 2 |
| e-ISSN | 15734838 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2007-07-10 |
| Publisher Place | Boston |
| Access Restriction | Subscribed |
| Subject Keyword | Surfaces and Interfaces, Thin Films Ceramics, Glass, Composites, Natural Methods Metallic Materials Polymer Sciences Characterization and Evaluation of Materials Biomaterials |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biophysics Bioengineering Biomedical Engineering |
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