NDLI: Evaluation of mechanical property and bioactivity of nano-bioglass 45S5 scaffold coated with poly-3-hydroxybutyrate

Content Provider	Springer Nature Link
Author	Montazeri, Mahbobeh Karbasi, Saeed Foroughi, Mohammad Reza Monshi, Ahmad Ebrahimi Kahrizsangi, Reza
Copyright Year	2015
Abstract	One of the major challenges facing researchers of tissue engineering is scaffold design with desirable physical and mechanical properties for growth and proliferation of cells and tissue formation. In this research, firstly, nano-bioglass powder with grain sizes of 55–56 nm was prepared by melting method of industrial raw materials at 1,400 °C. Then the porous ceramic scaffold of bioglass with 30, 40 and 50 wt% was prepared by using the polyurethane sponge replication method. The scaffolds were coated with poly-3-hydroxybutyrate (P3HB) for 30 s and 1 min in order to increase the scaffold’s mechanical properties. XRD, XRF, SEM, FE-SEM and FT-IR were used for phase and component studies, morphology, particle size and determination of functional groups, respectively. XRD and XRF results showed that the type of the produced bioglass was 45S5. The results of XRD and FT-IR showed that the best temperature to produce bioglass scaffold was 600 °C, in which Na$_{2}$Ca$_{2}$Si$_{3}$O$_{9}$ crystal is obtained. By coating the scaffolds with P3HB, a composite scaffold with optimal porosity of 80–87 % in 200–600 μm and compression strength of 0.1–0.53 MPa was obtained. According to the results of compressive strength and porosity tests, the best kind of scaffold was produced with 30 wt% of bioglass immersed for 1 min in P3HB. To evaluate the bioactivity of the scaffold, the SBF solution was used. The selected scaffold (30 wt% bioglass/6 wt% P3HB) was maintained for up to 4 weeks in this solution at an incubation temperature of 37 °C. The XRD, SEM EDXA and AAS tests were indicative of hydroxyapatite formation on the surface of bioactive scaffold. This scaffold has some potential to use in bone tissue engineering.
Starting Page	1
Ending Page	11
Page Count	11
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	26
Issue Number	2
e-ISSN	15734838
Language	English
Publisher	Springer US
Publisher Date	2015-01-29
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Biomaterials Biomedical Engineering Regenerative Medicine/Tissue Engineering Polymer Sciences Ceramics, Glass, Composites, Natural Methods Surfaces and Interfaces, Thin Films
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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