NDLI: Biodegradable tube impla

Content Provider	Springer Nature Link
Author	Kivalo, M. Sirén, V. Raitta, C. Immonen, I.
Copyright Year	1999
Abstract	Although ocular drainage implants are manufactured from biocombatible materials to reduce foreign-body reaction, the formation of excessive scar tissue around the implant is a common cause for implant failure. In this study, the suitability of poly(D, L-lactide-co-glycolide) copolymer, impregnated with an antiproliferative agent retinoic acid, was evaluated as a material for biodegradable tubular implants, as well as the duration and magnitude of the intraocular pressure reduction obtained with the prototype implant. Subconjunctivally placed retinoid-impregnated polymer particles caused a milder inflammatory reaction than plain polymer, and the layer of connective tissue around the material was thinner after the follow-up period of 60 d. In the anterior chamber, the inflammatory response elicited by the material was milder than subconjunctivally. The plain polymer caused a transiently stronger reaction than the retinoid-impregnated polymer, but after 60 d no difference was evident between the two materials. In all operated eyes with the tubular implant, the intraocular pressure was statistically significantly lower (p<0.05) than in control eyes for 9 wk after the operation. The intraocular pressure of the eyes with the retinoid-impregnated implant was statistically significantly lower (p<0.05) than in eyes with a plain polymer implant for up to 7 wk post-operatively. However, the use of retinoid did not prolong the effective functioning time of the implants. © 1999 Kluwer Academic Publishers
Starting Page	53
Ending Page	58
Page Count	6
File Format	PDF
ISSN	09574530
Journal	Journal of Materials Science: Materials in Medicine
Volume Number	10
Issue Number	1
e-ISSN	15734838
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	1999-01-01
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	Biotechnology Polymer Sciences Characterization and Evaluation Materials
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biophysics Bioengineering Biomedical Engineering

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