NDLI: DNA sequencing with nanopores from an ab initio perspective

Content Provider	Springer Nature Link
Author	Scheicher, Ralph H. Grigoriev, Anton Ahuja, Rajeev
Copyright Year	2012
Abstract	Advances in materials research means that we find ourselves at the verge of constructing nano-scale devices capable of electrically addressing individual molecules in order to identify or utilize their electrical or electromechanical properties. An important application in life sciences would be electromechanical translocation of a DNA molecule through a nanopore, between nano-scale electrodes, allowing to electrically read out the base sequence (genome). This approach promises to drastically lower the cost per genome, allowing for extensive application in medical diagnostics. Owing to the involved extremely small dimensions which require nanometer-resolution in the fabrication, atomistic modeling plays a crucial role in testing hypothetical device architectures for their performance in nucleobase distinction. First-principles simulations are ideally suited to explore the interactions involved in such scenarios and lay the foundation for electronic transport calculations. This role of computations is even more important here, since it is experimentally not possible to observe directly the kinetics occurring during translocation of a DNA molecule through a nanopore. Here, we provide a brief review of the state of the field, focusing on ab initio studies of nanopore-based DNA sequencing, in particular on the promising recent development regarding graphene nanopores and nanogaps.
Starting Page	7439
Ending Page	7446
Page Count	8
File Format	PDF
ISSN	00222461
Journal	Journal of Materials Science
Volume Number	47
Issue Number	21
e-ISSN	15734803
Language	English
Publisher	Springer US
Publisher Date	2012-07-03
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Characterization and Evaluation of Materials Crystallography Mechanics Materials Science Polymer Sciences Continuum Mechanics and Mechanics of Materials
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Mechanics of Materials Mechanical Engineering Polymers and Plastics

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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