NDLI: Morphological, mechanical, and biocompatibility characterization of macroporous alumina scaffolds coated with calcium phosphate/PVA

Content Provider	Springer Nature Link
Author	Costa, Hermes S. Mansur, Alexandra A. P. Barbosa Stancioli, Edel F. Pereira, Marivalda M. Mansur, Herman S.
Copyright Year	2007
Abstract	In bone tissue engineering, a highly porous artificial extracellular matrix or scaffold is required to accommodate cells and guide the tissue regeneration in three-dimension. Calcium phosphate (CaP) ceramics are widely used for bone substitution and repair due to their biocompatibility, bioactivity, and osteoconduction. However, compared to alumina ceramics, either in the dense or porous form, the mechanical strength achieved for calcium phosphates is generally lower. In the present work, the major goal was to develop a tri-dimensional macroporous alumina scaffold with a biocompatible PVA/calcium phosphate coating to be potentially used as bone tissue substitute. This approach aims to combine the high mechanical strength of the alumina scaffold with the biocompatibility of calcium phosphate based materials. Hence, the porous alumina scaffolds were produced by the polymer foam replication procedure. Then, these scaffolds were submitted to two different coating methods: the biomimetic and the immersion in a calcium phosphate/polyvinyl alcohol (CaP/PVA) slurry. The microstructure, morphology and crystallinity of the macroporous alumina scaffolds samples and coated with CaP/PVA were characterized by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM/EDX) analysis. Also, specific surface area was assessed by BET nitrogen adsorption method and mechanical behavior was evaluated by axial compression tests. Finally, biocompatibility and cytotoxicity were evaluated by VERO cell spreading and attachment assays under SEM. The morphological analysis obtained from SEM photomicrograph results has indicated that 3D macroporous alumina scaffolds were successfully produced, with estimated porosity of over 65% in a highly interconnected network. In addition, the mechanical test results have indicated that porous alumina scaffolds with ultimate compressive strength of over 3.0 MPa were produced. Concerning to the calcium phosphate coatings, the results have showed that the biomimetic method was not efficient on producing a detectable layer onto the alumina scaffolds. On the other hand, a uniform and adherent inorganic–organic coating was effectively formed onto alumina macroporous scaffold by the immersion of the porous structure into the CaP/PVA suspension. Viable VERO cells were verified onto the surface of alumina porous scaffold samples coated with PVA–calcium phosphate. In conclusion, a new method was developed to produce alumina with tri-dimensional porous structure and uniformly covered with a biocompatible coating of calcium phosphate/PVA. Such system has high potential to be used in bone tissue engineering.
Starting Page	510
Ending Page	524
Page Count	15
File Format	PDF
ISSN	00222461
Journal	Journal of Materials Science
Volume Number	43
Issue Number	2
e-ISSN	15734803
Language	English
Publisher	Springer US
Publisher Date	2007-07-20
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mechanics Crystallography Continuum Mechanics and Mechanics of Materials Polymer Sciences Characterization and Evaluation of Materials Materials Science
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Mechanics of Materials Mechanical Engineering Polymers and Plastics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Alumina-coated hollow glass spheres/alumina composites

Macroporous alumina monoliths prepared by filling polymer foams with alumina hydrosols

Synthesis and characterization of porous κ-carrageenan/calcium phosphate nanocomposite scaffolds

Feasibility of three-dimensional macroporous scaffold using calcium phosphate glass and polyurethane sponge

Fabrication and characterization of porous calcium polyphosphate scaffolds

Immersion characteristics of electrolytic calcium phosphate coated Ti in simulated physiological fluid

Preparation and characterization of carbon-coated ZnO and CaO powders by pyrolysis of PVA

Synthesis of alpha-alumina nanoribbons: characterization and their morphological evolution

Polymer-bioceramic composites for tissue engineering scaffolds

Morphological, mechanical, and biocompatibility characterization of macroporous alumina scaffolds coated with calcium phosphate/PVA

Similar Documents

Alumina-coated hollow glass spheres/alumina composites

Macroporous alumina monoliths prepared by filling polymer foams with alumina hydrosols

Synthesis and characterization of porous κ-carrageenan/calcium phosphate nanocomposite scaffolds

Feasibility of three-dimensional macroporous scaffold using calcium phosphate glass and polyurethane sponge

Fabrication and characterization of porous calcium polyphosphate scaffolds

Immersion characteristics of electrolytic calcium phosphate coated Ti in simulated physiological fluid

Preparation and characterization of carbon-coated ZnO and CaO powders by pyrolysis of PVA

Synthesis of alpha-alumina nanoribbons: characterization and their morphological evolution

Polymer-bioceramic composites for tissue engineering scaffolds

Morphological, mechanical, and biocompatibility characterization of macroporous alumina scaffolds coated with calcium phosphate/PVA