NDLI: Kinetic study of controlled release of VPA and DPH antiepileptic drugs using biocompatible nanostructured sol–gel TiO$

Content Provider	Springer Nature Link
Author	López, T. Alexander Katz, R. Castillo, P. González, M. Manjarrez, J. Gonzalez, R. D. Ilharco, L. Fidalgo, A. Rieumont, J.
Copyright Year	2009
Abstract	Sol–gel TiO$_{2}$ porous matrix was used to host valproic acid (VPA) and phenytoin (DPH), which are commonly used as antiepileptic drugs. The addition of these drugs was carried out during the synthesis in the hydrolysis stage. In vitro short term kinetic studies on drug liberation showed that almost all samples followed a first order kinetics with the exception of one sample which had a linear behavior. High resolution electron microscopy revealed the existence of nanocrystalinity in all samples, however, electron diffraction patterns showed that some were predominantly amorphous while in others suggested a greater density of nanocrystals. NMR studies demonstrated that VPA was less mobile in a more crystalline TiO$_{2}$ matrix than when the TiO$_{2}$ is mainly amorphous. Some features of the kinetics of drug liberation are explained in terms of the competition between nanocrystallinity and drug content. The reservoirs were implanted by means of stereotactic surgery in Wistar rats in which epilepsy was previously induced following the Kindling model of epilepsy. The efficiency of the reservoirs was follow by electroencephalography (EEGs). In vivo studies revealed that a more crystalline sample was more effective in preventing further epileptic events than samples with a higher content of VPA but predominantly amorphous.
Starting Page	5459
Ending Page	5468
Page Count	10
File Format	PDF
ISSN	00222461
Journal	Journal of Materials Science
Volume Number	44
Issue Number	20
e-ISSN	15734803
Language	English
Publisher	Springer US
Publisher Date	2009-08-06
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mechanics Crystallography Continuum Mechanics and Mechanics of Materials Polymer Sciences Characterization and Evaluation of Materials Materials Science
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Mechanics of Materials Mechanical Engineering Polymers and Plastics

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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