NDLI: Silk microfiber-reinforced silk composite scaffolds: fabrication, mechanical properties, and cytocompatibility

Content Provider	Springer Nature Link
Author	Li, Gang Li, Fei Zheng, Zhaozhu Luo, Tingting Liu, Jian Wu, Jianbing Wang, Xiaoqin Kaplan, David L.
Copyright Year	2015
Abstract	Mechanical reinforcement of silk membranes by embedding silk microfibers was studied. Silk microfibers of 10–600 μm long were prepared by hydrolyzing degummed silk fibers in alkali solution. The silk microfibers were mixed with silk fibroin solution (continuous phase) at various ratios to fabricate silk microfiber-reinforced composite scaffolds (SMCSs). The morphology, mechanical properties, structural characteristics, biodegradation, and cytotoxicity of the composites were investigated. Silk microfiber-reinforced membranes with 1 wt% of microfibers displayed the most homogeneous distribution of microfibers in the membrane matrix. The tensile strength and elongation at break were 10.5 ± 2.7 MPa and 56.7 ± 7.8 %, respectively, comparable to human meniscus tissue. The presence of silk microfibers did not significantly impact the secondary structure and crystallization of SMCSs. Proteolytic degradation in vitro using protease XIV showed that the 1 % silk microfiber-reinforced membranes lost 90 % weight after 5 days, a longer time frame than plain silk membrane controls. The viability of human fibroblasts (Hs 865.Sk) on the SMCSs demonstrated no cytotoxicity. SMCSs may be useful as biomaterial systems as tissue substitutes where mechanical strength is critical for functional performance.
Starting Page	3025
Ending Page	3035
Page Count	11
File Format	PDF
ISSN	00222461
Journal	Journal of Materials Science
Volume Number	51
Issue Number	6
e-ISSN	15734803
Language	English
Publisher	Springer US
Publisher Date	2015-11-30
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Materials Science Characterization and Evaluation of Materials Polymer Sciences Continuum Mechanics and Mechanics of Materials Crystallography Mechanics
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Mechanics of Materials Mechanical Engineering Polymers and Plastics

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