NDLI: Kafirin polymer film for enteric coating on HPMC and Gelatin capsules

Content Provider	Springer Nature Link
Author	Lal, Sumit S. Tanna, Pooja Kale, Sandeep Mhaske, Shashank T.
Copyright Year	2016
Abstract	Protein-based materials have attracted a tremendous attention to the growth of polymer films and protein-based coating. Efficiency of Kafirin film and effect of Kafirin film as an enteric coating for drug release was studied. The cast films with varying plasticizer concentrations (polyethylene glycol-300) were tested for mechanical tests (Tensile, Young’s, Elongation) and further analyzed with DSC and TGA analysis. Swelling behavior and FTIR were performed to ensure medium uptake and inter- and intra-molecule structural changes. All together for enteric coating, capsules filled with Paracetamol were dip coated in Kafirin solution with 20, 30, and 40% of PEG plasticizer of drug release study. Dissolution studies demonstrated zero release upon exposure to 0.1 N HCl of pH 1.2 for initial 2 h, and gradual release was observed upon exposure to phosphate buffer of pH 6.8. The effect of plasticizer concentration was noticeable in the case of HPMC capsules, and drug release declined with the increasing plasticizer content. Whereas, in case of Gelatin opposite results were obtained. This work has shown that Kafirin protein has a potential for use as an enteric coating for drug delivery application.
Starting Page	3806
Ending Page	3820
Page Count	15
File Format	PDF
ISSN	00222461
Journal	Journal of Materials Science
Volume Number	52
Issue Number	7
e-ISSN	15734803
Language	English
Publisher	Springer US
Publisher Date	2016-12-09
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Materials Science Characterization and Evaluation of Materials Polymer Sciences Continuum Mechanics and Mechanics of Materials Crystallography and Scattering Methods Classical Mechanics
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Mechanics of Materials Mechanical Engineering Polymers and Plastics

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